HCSGD entry for RAD17
1. General information
| Official gene symbol | RAD17 |
|---|---|
| Entrez ID | 5884 |
| Gene full name | RAD17 homolog (S. pombe) |
| Other gene symbols | CCYC HRAD17 R24L RAD17SP RAD24 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000076 | DNA replication checkpoint | TAS | biological_process |
| GO:0000077 | DNA damage checkpoint | IMP | biological_process |
| GO:0000781 | Chromosome, telomeric region | IDA | cellular_component |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006260 | DNA replication | TAS | biological_process |
| GO:0006281 | DNA repair | IEA | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | IEA IMP | biological_process |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0007093 | Mitotic cell cycle checkpoint | IMP | biological_process |
| GO:0008156 | Negative regulation of DNA replication | IMP | biological_process |
| GO:0017111 | Nucleoside-triphosphatase activity | IEA | molecular_function |
| GO:0042325 | Regulation of phosphorylation | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9816712587 | 0.0621361081 | 0.9999902473 | 0.4699668103 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0865184827 |
| GSE13712_SHEAR | Down | -0.1196931971 |
| GSE13712_STATIC | Down | -0.2143141807 |
| GSE19018 | Down | -0.0032334406 |
| GSE19899_A1 | Down | -0.3828147128 |
| GSE19899_A2 | Down | -0.4347295007 |
| PubMed_21979375_A1 | Down | -0.8337756676 |
| PubMed_21979375_A2 | Down | -0.5149512103 |
| GSE35957 | Down | -0.1183018831 |
| GSE36640 | Down | -0.1398453871 |
| GSE54402 | Down | -0.1935738795 |
| GSE9593 | Up | 0.0858772396 |
| GSE43922 | Down | -0.2005832598 |
| GSE24585 | Up | 0.3446112265 |
| GSE37065 | Up | 0.0109180870 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.4358330848 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 17535972 | We detected accumulation of aberrant V(D)J recombination-related DSBs at the T cell receptor (TCR) locus, and high expression levels of both mutant p53 and cell cycle checkpoint protein p21, but not the apoptotic protein p53-upregulated modulator of apoptosis |
| 11333225 | Mec1p is a cell cycle checkpoint protein related to the ATM protein kinase family |
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