HCSGD entry for RAD9A
1. General information
| Official gene symbol | RAD9A |
|---|---|
| Entrez ID | 5883 |
| Gene full name | RAD9 homolog A (S. pombe) |
| Other gene symbols | RAD9 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000076 | DNA replication checkpoint | TAS | biological_process |
| GO:0000077 | DNA damage checkpoint | IEA IMP | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006260 | DNA replication | TAS | biological_process |
| GO:0006281 | DNA repair | IEA | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | IDA | biological_process |
| GO:0008408 | 3'-5' exonuclease activity | IDA | molecular_function |
| GO:0008853 | Exodeoxyribonuclease III activity | IEA | molecular_function |
| GO:0017124 | SH3 domain binding | IPI | molecular_function |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
| GO:0030896 | Checkpoint clamp complex | IEA | cellular_component |
| GO:0031573 | Intra-S DNA damage checkpoint | IEA | biological_process |
| GO:0042826 | Histone deacetylase binding | IPI | molecular_function |
| GO:0071479 | Cellular response to ionizing radiation | IDA | biological_process |
| GO:0090305 | Nucleic acid phosphodiester bond hydrolysis | IDA | biological_process |
| GO:1902231 | Positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9329263782 | 0.2077921394 | 0.9999902473 | 0.8831855990 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2548984619 |
| GSE13712_SHEAR | Down | -0.2941247862 |
| GSE13712_STATIC | Up | 0.4206579536 |
| GSE19018 | Down | -0.0048831121 |
| GSE19899_A1 | Down | -0.1814506957 |
| GSE19899_A2 | Down | -0.4519004553 |
| PubMed_21979375_A1 | Down | -0.3032925261 |
| PubMed_21979375_A2 | Up | 0.0989610909 |
| GSE35957 | Down | -0.5283321749 |
| GSE36640 | Down | -0.1503423413 |
| GSE54402 | Down | -0.0269740622 |
| GSE9593 | Down | -0.0899696692 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.1657017092 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-196a-5p | MIMAT0000226 | MIRT026047 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-let-7d-5p | MIMAT0000065 | MIRT032159 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 15760303 | After DNA damage, activation of Rad53, which together with Chk1 represents a protein kinase central to all checkpoint pathways, normally requires Rad9, a checkpoint adaptor |
| 15760303 | RESULTS: We report that in telomerase-negative (tlc1Delta) cells, activation of Rad53, although diminished, could still take place in the absence of Rad9 |
| 15760303 | In contrast, Rad9 was essential for Rad53 activation in cells that entered senescence in the presence of functional telomerase, namely in senescent cells bearing mutations in telomere end-protection proteins (cdc13-1 yku70Delta) |
| 15760303 | In telomerase-negative cells deleted for RAD9, Mrc1, another checkpoint adaptor previously implicated in the DNA replication checkpoint, mediated Rad53 activation |
| 15760303 | Rad9 and Rad53, as well as other DNA damage checkpoint proteins (Mec1, Mec3, Chk1 and Dun1), were required for complete DNA-damage-induced cell-cycle arrest after loss of telomerase function |
| 15760303 | Finally, we report that Rad9, Mrc1, Dun1 and Chk1 are activated by phosphorylation after telomerase inactivation |
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