HCSGD entry for RAC2

1. General information

Official gene symbolRAC2
Entrez ID5880
Gene full nameras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
Other gene symbolsEN-7 Gx HSPC022
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003924GTPase activityIEAmolecular_function
GO:0005525GTP bindingIEAmolecular_function
GO:0005622IntracellularIEAcellular_component
GO:0005635Nuclear envelopeIEAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006935ChemotaxisIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007264Small GTPase mediated signal transductionIEA TASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0010310Regulation of hydrogen peroxide metabolic processTASbiological_process
GO:0016020MembraneIEAcellular_component
GO:0030031Cell projection assemblyIEAbiological_process
GO:0030036Actin cytoskeleton organizationIEAbiological_process
GO:0030168Platelet activationTASbiological_process
GO:0045453Bone resorptionIEAbiological_process
GO:0051056Regulation of small GTPase mediated signal transductionTASbiological_process
GO:0060263Regulation of respiratory burstIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00020487060.55057393720.04180155041.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up1.6492454408
GSE13712_SHEARUp0.5413172891
GSE13712_STATICUp0.8504162613
GSE19018Up0.3757013570
GSE19899_A1Up2.9722576450
GSE19899_A2Up3.9442906951
PubMed_21979375_A1Up2.7049591496
PubMed_21979375_A2Up2.2697888835
GSE35957Down-0.4341715475
GSE36640Down-0.9768594549
GSE54402Up1.6283634290
GSE9593Up0.8504092649
GSE43922Up1.8625107657
GSE24585Up0.1992921118
GSE37065Down-0.3493352754
GSE28863_A1Down-0.5147563737
GSE28863_A2Down-0.6507426774
GSE28863_A3Up0.0229386752
GSE28863_A4Up0.1023694944
GSE48662Down-0.2933887940

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

DextromethorphanDB00514 APRD00655

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-193b-3pMIMAT0002819MIRT016574MicroarrayFunctional MTI (Weak)20304954
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.