HCSGD entry for MAP4K2
1. General information
| Official gene symbol | MAP4K2 |
|---|---|
| Entrez ID | 5871 |
| Gene full name | mitogen-activated protein kinase kinase kinase kinase 2 |
| Other gene symbols | BL44 GCK RAB8IP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA | cellular_component |
| GO:0000185 | Activation of MAPKKK activity | IBA | biological_process |
| GO:0004672 | Protein kinase activity | IEA | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IDA IEA | molecular_function |
| GO:0005083 | Small GTPase regulator activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IDA IEA | molecular_function |
| GO:0005737 | Cytoplasm | IBA | cellular_component |
| GO:0006468 | Protein phosphorylation | IDA | biological_process |
| GO:0006903 | Vesicle targeting | IEA | biological_process |
| GO:0006950 | Response to stress | TAS | biological_process |
| GO:0006955 | Immune response | TAS | biological_process |
| GO:0007254 | JNK cascade | TAS | biological_process |
| GO:0007257 | Activation of JUN kinase activity | IDA | biological_process |
| GO:0008349 | MAP kinase kinase kinase kinase activity | IBA | molecular_function |
| GO:0016323 | Basolateral plasma membrane | IEA | cellular_component |
| GO:0031435 | Mitogen-activated protein kinase kinase kinase binding | IPI | molecular_function |
| GO:0035556 | Intracellular signal transduction | IDA | biological_process |
| GO:0045087 | Innate immune response | IEA | biological_process |
| GO:0046330 | Positive regulation of JNK cascade | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3825602979 | 0.4688704570 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1125609578 |
| GSE13712_SHEAR | Down | -0.0258057188 |
| GSE13712_STATIC | Down | -0.1034097157 |
| GSE19018 | Up | 0.1024918599 |
| GSE19899_A1 | Down | -0.0297422303 |
| GSE19899_A2 | Up | 0.8595514469 |
| PubMed_21979375_A1 | Up | 0.1977180218 |
| PubMed_21979375_A2 | Up | 0.3519193010 |
| GSE35957 | Down | -0.4765452839 |
| GSE36640 | Up | 0.0054566271 |
| GSE54402 | Up | 0.3790248503 |
| GSE9593 | Down | -0.1610993152 |
| GSE43922 | Up | 0.1138842674 |
| GSE24585 | Up | 0.2951531225 |
| GSE37065 | Down | -0.0435376158 |
| GSE28863_A1 | Down | -0.2932195701 |
| GSE28863_A2 | Down | -0.2368896989 |
| GSE28863_A3 | Down | -0.0340824569 |
| GSE28863_A4 | Up | 0.0139028039 |
| GSE48662 | Down | -0.0659643461 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT024097 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
