HCSGD entry for BCAT2
1. General information
| Official gene symbol | BCAT2 |
|---|---|
| Entrez ID | 587 |
| Gene full name | branched chain amino-acid transaminase 2, mitochondrial |
| Other gene symbols | BCAM BCATM BCT2 PP18 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004084 | Branched-chain-amino-acid transaminase activity | EXP IEA | molecular_function |
| GO:0005739 | Mitochondrion | IEA TAS | cellular_component |
| GO:0005759 | Mitochondrial matrix | TAS | cellular_component |
| GO:0006550 | Isoleucine catabolic process | IEA | biological_process |
| GO:0006551 | Leucine metabolic process | IEA | biological_process |
| GO:0006573 | Valine metabolic process | IEA | biological_process |
| GO:0009082 | Branched-chain amino acid biosynthetic process | IEA | biological_process |
| GO:0009083 | Branched-chain amino acid catabolic process | TAS | biological_process |
| GO:0010817 | Regulation of hormone levels | IEA | biological_process |
| GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0052654 | L-leucine transaminase activity | IEA | molecular_function |
| GO:0052655 | L-valine transaminase activity | IEA | molecular_function |
| GO:0052656 | L-isoleucine transaminase activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9435175601 | 0.1748807910 | 0.9999902473 | 0.8092217964 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3247899113 |
| GSE13712_SHEAR | Down | -0.0724370135 |
| GSE13712_STATIC | Up | 0.0788374162 |
| GSE19018 | Up | 0.1291736855 |
| GSE19899_A1 | Down | -0.0984562241 |
| GSE19899_A2 | Up | 0.1031472523 |
| PubMed_21979375_A1 | Up | 0.2303159498 |
| PubMed_21979375_A2 | Up | 0.0859552974 |
| GSE35957 | Up | 0.0271911694 |
| GSE36640 | Down | -0.0212747805 |
| GSE54402 | Down | -0.0691290542 |
| GSE9593 | Down | -0.1552489325 |
| GSE43922 | Up | 0.0366645403 |
| GSE24585 | Down | -0.3867544421 |
| GSE37065 | Down | -0.4748330395 |
| GSE28863_A1 | Down | -0.0048338413 |
| GSE28863_A2 | Down | -0.1763852260 |
| GSE28863_A3 | Down | -0.0687305017 |
| GSE28863_A4 | Up | 0.0777955817 |
| GSE48662 | Down | -0.4125783884 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| L-Glutamic Acid | DB00142 | NUTR00027 |
| L-Leucine | DB00149 | NUTR00033 |
| L-Isoleucine | DB00167 | NUTR00031 |
| Pyridoxamine-5'-Phosphate | DB02142 | EXPT02621 |
| N-[O-Phosphono-Pyridoxyl]-Isoleucine | DB02635 | EXPT01863 |
| Alpha-ketoisovalerate | DB04074 | EXPT01974 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-32-5p | MIMAT0000090 | MIRT028382 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040021 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041917 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
