HCSGD entry for RAB5A
1. General information
| Official gene symbol | RAB5A |
|---|---|
| Entrez ID | 5868 |
| Gene full name | RAB5A, member RAS oncogene family |
| Other gene symbols | RAB5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001726 | Ruffle | IEA | cellular_component |
| GO:0003924 | GTPase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005525 | GTP binding | IDA IEA | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005769 | Early endosome | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0006184 | GTP catabolic process | IDA TAS | biological_process |
| GO:0006897 | Endocytosis | IDA | biological_process |
| GO:0007264 | Small GTPase mediated signal transduction | IEA | biological_process |
| GO:0007399 | Nervous system development | IEA | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0010008 | Endosome membrane | TAS | cellular_component |
| GO:0015031 | Protein transport | IEA | biological_process |
| GO:0015629 | Actin cytoskeleton | IEA | cellular_component |
| GO:0019003 | GDP binding | IDA | molecular_function |
| GO:0030139 | Endocytic vesicle | IEA | cellular_component |
| GO:0030154 | Cell differentiation | IEA | biological_process |
| GO:0031901 | Early endosome membrane | IEA | cellular_component |
| GO:0042470 | Melanosome | IEA | cellular_component |
| GO:0045121 | Membrane raft | IEA | cellular_component |
| GO:0045921 | Positive regulation of exocytosis | IMP | biological_process |
| GO:0051489 | Regulation of filopodium assembly | IDA | biological_process |
| GO:2000286 | Receptor internalization involved in canonical Wnt signaling pathway | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2903923597 | 0.8680389993 | 0.9896025628 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1394570474 |
| GSE13712_SHEAR | Down | -0.0504060043 |
| GSE13712_STATIC | Down | -0.1657710211 |
| GSE19018 | Up | 0.3950149593 |
| GSE19899_A1 | Up | 0.1500856722 |
| GSE19899_A2 | Down | -0.0239120963 |
| PubMed_21979375_A1 | Down | -0.1269034174 |
| PubMed_21979375_A2 | Down | -0.1391271900 |
| GSE35957 | Up | 0.1257618526 |
| GSE36640 | Up | 0.3373302403 |
| GSE54402 | Up | 0.2803175941 |
| GSE9593 | Up | 0.3670171249 |
| GSE43922 | Up | 0.0450997773 |
| GSE24585 | Up | 0.1904755097 |
| GSE37065 | Up | 0.0838790254 |
| GSE28863_A1 | Up | 0.0046944324 |
| GSE28863_A2 | Up | 0.0631676488 |
| GSE28863_A3 | Down | -0.3701872470 |
| GSE28863_A4 | Down | -0.2738475598 |
| GSE48662 | Up | 0.0336633326 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| L-methionine (S)-S-oxide | DB02467 | EXPT02173 |
| Guanosine-5'-Triphosphate | DB04137 | EXPT01660 |
| Guanosine-5'-Diphosphate | DB04315 | EXPT01573 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-101-3p | MIMAT0000099 | MIRT006150 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-130a-3p | MIMAT0000425 | MIRT007138 | qRT-PCR | Functional MTI (Weak) | 23418453 |
| hsa-miR-130b-3p | MIMAT0000691 | MIRT020340 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-33a-5p | MIMAT0000091 | MIRT028241 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-18a-5p | MIMAT0000072 | MIRT031351 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 20127045 | Interestingly, addition of the dominant-negative mutant of Rab5, a small G-protein Rab5 involved in the endocytic process, inhibits the aging-related APP-BACE1 interaction and Abeta production, suggesting that endocytosis contributes to AD progression |
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