HCSGD entry for RAB1A
1. General information
| Official gene symbol | RAB1A |
|---|---|
| Entrez ID | 5861 |
| Gene full name | RAB1A, member RAS oncogene family |
| Other gene symbols | RAB1 YPT1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000045 | Autophagic vacuole assembly | IMP | biological_process |
| GO:0000139 | Golgi membrane | TAS | cellular_component |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0003924 | GTPase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0005783 | Endoplasmic reticulum | IEA | cellular_component |
| GO:0006184 | GTP catabolic process | IDA | biological_process |
| GO:0006888 | ER to Golgi vesicle-mediated transport | IMP | biological_process |
| GO:0006897 | Endocytosis | IMP | biological_process |
| GO:0006914 | Autophagy | IMP | biological_process |
| GO:0007264 | Small GTPase mediated signal transduction | IEA | biological_process |
| GO:0015031 | Protein transport | IEA | biological_process |
| GO:0016192 | Vesicle-mediated transport | TAS | biological_process |
| GO:0016477 | Cell migration | IMP | biological_process |
| GO:0030252 | Growth hormone secretion | IMP | biological_process |
| GO:0042742 | Defense response to bacterium | IMP | biological_process |
| GO:0047496 | Vesicle transport along microtubule | IMP | biological_process |
| GO:0072606 | Interleukin-8 secretion | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7680415676 | 0.5477293150 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0522315972 |
| GSE13712_SHEAR | Up | 0.0275569763 |
| GSE13712_STATIC | Up | 0.1372352793 |
| GSE19018 | Down | -0.0281034883 |
| GSE19899_A1 | Up | 0.0603933721 |
| GSE19899_A2 | Down | -0.0188801014 |
| PubMed_21979375_A1 | Down | -0.0369546871 |
| PubMed_21979375_A2 | Down | -0.1187972266 |
| GSE35957 | Up | 0.1939342750 |
| GSE36640 | Up | 0.1549507111 |
| GSE54402 | Up | 0.0840858386 |
| GSE9593 | Up | 0.0655846670 |
| GSE43922 | Up | 0.0966558997 |
| GSE24585 | Down | -0.3145886794 |
| GSE37065 | Down | -0.0377253136 |
| GSE28863_A1 | Up | 0.0042596865 |
| GSE28863_A2 | Up | 0.5158663444 |
| GSE28863_A3 | Down | -0.2420709459 |
| GSE28863_A4 | Down | -0.1901110685 |
| GSE48662 | Down | -0.3901997335 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-215-5p | MIMAT0000272 | MIRT024685 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026737 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT031267 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031831 | Proteomics | Functional MTI (Weak) | 18668040 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26165933 | Bioinformatics analyses suggested that Rab1a and Rab31, which are associated with cell autophagy, were targeted by both miR-184 and miR-150 |
| 26165933 | Furthermore, dual luciferase reporter assays revealed that miR-184 and miR-150 bound to the 3'-UTR of Rab1a and Rab31 mRNAs |
| 26165933 | Transfection of miR-184 and miR-150 mimics into young GMCs suppressed the expression of Rab1a and Rab31 |
| 26165933 | However, miR-184 and miR-150 inhibitors promoted autophagy and reduced oxidative damage by upregulating Rab1a and Rab31 in old GMCs |
| 23466301 | In particular, the expression levels of 9 genes, HSP90B1, EID1, ATP2B4, DDAH1, PRNP, RAB1A, PGS5, TM4SF1 and SSR3, gradually increased during senescence |
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