HCSGD entry for NLRC4

1. General information

Official gene symbolNLRC4
Entrez ID58484
Gene full nameNLR family, CARD domain containing 4
Other gene symbolsCARD12 CLAN CLAN1 CLANA CLANB CLANC CLAND CLR2.1 IPAF
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000287Magnesium ion bindingTASmolecular_function
GO:0002218Activation of innate immune responseISSbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIDAmolecular_function
GO:0005622IntracellularNAScellular_component
GO:0005829CytosolISS TAScellular_component
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processIDAbiological_process
GO:0006954Inflammatory responseISSbiological_process
GO:0016045Detection of bacteriumIDAbiological_process
GO:0035872Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayTASbiological_process
GO:0042742Defense response to bacteriumIDAbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0043065Positive regulation of apoptotic processIDAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0050702Interleukin-1 beta secretionIDAbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityIDAbiological_process
GO:0051260Protein homooligomerizationISSbiological_process
GO:0070269PyroptosisISSbiological_process
GO:0072557IPAF inflammasome complexISScellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.44095658600.95025782830.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1675965376
GSE13712_SHEARUp0.0149790461
GSE13712_STATICUp0.1017023917
GSE19018Up0.1101657455
GSE19899_A1Up0.1821979722
GSE19899_A2Up0.0219656522
PubMed_21979375_A1Up0.1402696895
PubMed_21979375_A2Up0.0064414696
GSE35957Up0.0079679347
GSE36640Up0.1095875201
GSE54402Up0.0828047560
GSE9593Up0.1764397756
GSE43922Up0.0180951815
GSE24585Down-0.0568442416
GSE37065Down-0.0455674899
GSE28863_A1Up0.0102784275
GSE28863_A2Up0.0055309641
GSE28863_A3Up0.1950801164
GSE28863_A4Up0.0645946436
GSE48662Up0.0066399260

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017182MicroarrayFunctional MTI (Weak)18185580
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.