HCSGD entry for PYGL

1. General information

Official gene symbolPYGL
Entrez ID5836
Gene full namephosphorylase, glycogen, liver
Other gene symbolsGSD6
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002060Purine nucleobase bindingIDAmolecular_function
GO:0005524ATP bindingIDAmolecular_function
GO:0005536Glucose bindingNASmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005975Carbohydrate metabolic processIEA TASbiological_process
GO:0005977Glycogen metabolic processIMPbiological_process
GO:0005980Glycogen catabolic processTASbiological_process
GO:0006006Glucose metabolic processTASbiological_process
GO:00060155-phosphoribose 1-diphosphate biosynthetic processIEAbiological_process
GO:0008144Drug bindingIDAmolecular_function
GO:0008184Glycogen phosphorylase activityEXP IDA IEA IMPmolecular_function
GO:0016208AMP bindingIDAmolecular_function
GO:0019842Vitamin bindingIDAmolecular_function
GO:0030170Pyridoxal phosphate bindingIEAmolecular_function
GO:0032052Bile acid bindingIDAmolecular_function
GO:0042593Glucose homeostasisIMPbiological_process
GO:0042803Protein homodimerization activityNASmolecular_function
GO:0044281Small molecule metabolic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.13097308230.05377465140.73501419440.4369848457

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.6587309794
GSE13712_SHEARUp0.1281580170
GSE13712_STATICUp0.4680250949
GSE19018Up0.5662313829
GSE19899_A1Up0.2944555491
GSE19899_A2Down-0.6963289349
PubMed_21979375_A1Down-0.1831821764
PubMed_21979375_A2Down-0.1060032437
GSE35957Down-0.0139978720
GSE36640Down-1.3276197274
GSE54402Up0.0360017235
GSE9593Down-0.1017750893
GSE43922Down-0.4017075649
GSE24585Up0.5395116231
GSE37065Down-0.6368450475
GSE28863_A1Up0.4757776242
GSE28863_A2Up0.7122992185
GSE28863_A3Down-0.7249033165
GSE28863_A4Down-0.1143452113
GSE48662Up0.1076732200

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

CP-526423DB02089 EXPT00994
1-N-Acetyl-Beta-D-GlucosamineDB02320 EXPT02300
Beta-D-GlucoseDB02379 EXPT00685 | EXPT00455 | EXPT01603
5-Chloro-1h-Indole-2-Carboxylic Acid{[Cyclopentyl-(2-Hydroxy-Ethyl)-Carbamoyl]-Methyl}-AmideDB03288 EXPT00098
Cp403700, (S)-1-{2-[(5-Chloro-1h-Indole-2-Carbonyl)-Amino]-3-Phenyl-Propionyl}-Azetidine-3-CarboxylateDB03744 EXPT00293
PhosphonoserineDB04522 EXPT02883
PSN357DB05044 -
5-chloro-N-{4-[(1R)-1,2-dihydroxyethyl]phenyl}-1H-indole-2-carboxamideDB07315 -
4-[3-(2-Chloro-4,5-difluoro-benzoyl)ureido]-3-trifluoromethoxybenzoic acidDB07395 -
1-{2-[3-(2-Chloro-4,5-difluoro-benzoyl)-ureido]-4-fluoro-phenyl}-piperidine-4-carboxylic acidDB07396 -
N-(2-CHLORO-4-FLUOROBENZOYL)-N'-(5-HYDROXY-2-METHOXYPHENYL)UREADB07968 -
Uric AcidDB08844 DB01696 | EXPT03202

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT021033ProteomicsFunctional MTI (Weak)18668040
hsa-miR-10a-5pMIMAT0000253MIRT047597CLASHFunctional MTI (Weak)23622248
hsa-miR-93-5pMIMAT0000093MIRT048878CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049286CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.