HCSGD entry for PYCR1
1. General information
| Official gene symbol | PYCR1 |
|---|---|
| Entrez ID | 5831 |
| Gene full name | pyrroline-5-carboxylate reductase 1 |
| Other gene symbols | ARCL2B ARCL3B P5C P5CR PIG45 PP222 PRO3 PYCR |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004735 | Pyrroline-5-carboxylate reductase activity | IDA IEA TAS | molecular_function |
| GO:0005739 | Mitochondrion | IDA IEA | cellular_component |
| GO:0005759 | Mitochondrial matrix | TAS | cellular_component |
| GO:0006561 | Proline biosynthetic process | IDA IEA | biological_process |
| GO:0008652 | Cellular amino acid biosynthetic process | TAS | biological_process |
| GO:0034599 | Cellular response to oxidative stress | IMP | biological_process |
| GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0055129 | L-proline biosynthetic process | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8568695566 | 0.0021920938 | 0.9999902473 | 0.0901532813 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4934413393 |
| GSE13712_SHEAR | Up | 0.4929916557 |
| GSE13712_STATIC | Up | 0.4167235255 |
| GSE19018 | Up | 0.2262954463 |
| GSE19899_A1 | Down | -0.8518020618 |
| GSE19899_A2 | Down | -1.4268193008 |
| PubMed_21979375_A1 | Down | -0.9813738454 |
| PubMed_21979375_A2 | Down | -2.5481630704 |
| GSE35957 | Down | -1.0565901598 |
| GSE36640 | Down | -0.2636527706 |
| GSE54402 | Down | -0.5423935397 |
| GSE9593 | Up | 0.0625781832 |
| GSE43922 | Down | -0.9482576737 |
| GSE24585 | Down | -0.6757977523 |
| GSE37065 | Down | -1.1076134582 |
| GSE28863_A1 | Down | -0.3802688078 |
| GSE28863_A2 | Down | -0.1838061157 |
| GSE28863_A3 | Up | 0.4640854367 |
| GSE28863_A4 | Up | 0.2628270014 |
| GSE48662 | Up | 0.2131025101 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| NADH | DB00157 | NUTR00041 | DB01907 | EXPT02287 | DB03527 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025563 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-940 | MIMAT0004983 | MIRT036631 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051571 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
