HCSGD entry for PXN
1. General information
| Official gene symbol | PXN |
|---|---|
| Entrez ID | 5829 |
| Gene full name | paxillin |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000187 | Activation of MAPK activity | IEA | biological_process |
| GO:0005178 | Integrin binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005856 | Cytoskeleton | IEA | cellular_component |
| GO:0005875 | Microtubule associated complex | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA TAS | cellular_component |
| GO:0005925 | Focal adhesion | IDA IEA | cellular_component |
| GO:0005938 | Cell cortex | IEA | cellular_component |
| GO:0006928 | Cellular component movement | IEA | biological_process |
| GO:0006936 | Muscle contraction | TAS | biological_process |
| GO:0007010 | Cytoskeleton organization | IEA | biological_process |
| GO:0007155 | Cell adhesion | NAS | biological_process |
| GO:0007160 | Cell-matrix adhesion | IEA | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007172 | Signal complex assembly | TAS | biological_process |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0007229 | Integrin-mediated signaling pathway | IEA | biological_process |
| GO:0008013 | Beta-catenin binding | IPI | molecular_function |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0017166 | Vinculin binding | IPI | molecular_function |
| GO:0018108 | Peptidyl-tyrosine phosphorylation | IEA | biological_process |
| GO:0019901 | Protein kinase binding | IEA | molecular_function |
| GO:0030027 | Lamellipodium | IDA IEA | cellular_component |
| GO:0030032 | Lamellipodium assembly | IEA | biological_process |
| GO:0034329 | Cell junction assembly | TAS | biological_process |
| GO:0034614 | Cellular response to reactive oxygen species | IEP | biological_process |
| GO:0048041 | Focal adhesion assembly | IEA | biological_process |
| GO:0048754 | Branching morphogenesis of an epithelial tube | IEA | biological_process |
| GO:0051435 | BH4 domain binding | IEA | molecular_function |
| GO:0060396 | Growth hormone receptor signaling pathway | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0053180540 | 0.9794749630 | 0.1907036785 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1808028466 |
| GSE13712_SHEAR | Up | 0.5913764591 |
| GSE13712_STATIC | Up | 0.4280781821 |
| GSE19018 | Down | -0.0978367084 |
| GSE19899_A1 | Up | 0.4929653034 |
| GSE19899_A2 | Up | 0.7294095280 |
| PubMed_21979375_A1 | Up | 1.2777712370 |
| PubMed_21979375_A2 | Up | 0.5693474536 |
| GSE35957 | Up | 0.1953228119 |
| GSE36640 | Up | 0.1467031283 |
| GSE54402 | Up | 1.4714428397 |
| GSE9593 | Up | 0.2605072514 |
| GSE43922 | Up | 0.4295942972 |
| GSE24585 | Down | -0.1267967933 |
| GSE37065 | Down | -0.0070991812 |
| GSE28863_A1 | Up | 0.1991502572 |
| GSE28863_A2 | Up | 0.4118025699 |
| GSE28863_A3 | Down | -0.1530005293 |
| GSE28863_A4 | Up | 0.0717175888 |
| GSE48662 | Up | 0.0528428299 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-137 | MIMAT0000429 | MIRT007346 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 23275153 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018650 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT023030 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT046850 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049136 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 15742196 | Among the focal adhesion proteins, paxillin and c-Src decreased also |
| 15263006 | We observed that the expression integrin beta(1) and focal adhesion kinase (FAK) were increased and that the phosphorylations of FAK and paxillin, hallmarks of focal adhesion formation, were also increased in senescent human diploid fibroblast cells |
| 10708479 | Hic-5 may therefore function, like paxillin, as a potential adapter for the recruitment of structural and signaling molecules to certain subcellular sites or in focal adhesions |
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