HCSGD entry for PURA
1. General information
| Official gene symbol | PURA |
|---|---|
| Entrez ID | 5813 |
| Gene full name | purine-rich element binding protein A |
| Other gene symbols | PUR-ALPHA PUR1 PURALPHA |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000784 | Nuclear chromosome, telomeric region | IC | cellular_component |
| GO:0000900 | Translation repressor activity, nucleic acid binding | IEA | molecular_function |
| GO:0003691 | Double-stranded telomeric DNA binding | IDA | molecular_function |
| GO:0003697 | Single-stranded DNA binding | ISS | molecular_function |
| GO:0003705 | RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005662 | DNA replication factor A complex | ISS | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006268 | DNA unwinding involved in DNA replication | IDA | biological_process |
| GO:0006270 | DNA replication initiation | TAS | biological_process |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0007399 | Nervous system development | IEA | biological_process |
| GO:0008134 | Transcription factor binding | ISS | molecular_function |
| GO:0008284 | Positive regulation of cell proliferation | IEA | biological_process |
| GO:0030425 | Dendrite | IEA | cellular_component |
| GO:0032422 | Purine-rich negative regulatory element binding | IEA | molecular_function |
| GO:0043025 | Neuronal cell body | IEA | cellular_component |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0046332 | SMAD binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4697275521 | 0.3851829186 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0009824185 |
| GSE13712_SHEAR | Down | -0.1352525002 |
| GSE13712_STATIC | Down | -0.1018348195 |
| GSE19018 | Down | -0.0377584067 |
| GSE19899_A1 | Down | -0.2466975660 |
| GSE19899_A2 | Up | 0.0192020393 |
| PubMed_21979375_A1 | Down | -0.7351058464 |
| PubMed_21979375_A2 | Down | -0.2598672815 |
| GSE35957 | Up | 0.4062381942 |
| GSE36640 | Up | 1.5503114760 |
| GSE54402 | Up | 0.3141650964 |
| GSE9593 | Up | 0.2901342731 |
| GSE43922 | Down | -0.0289239403 |
| GSE24585 | Up | 0.0031690979 |
| GSE37065 | Up | 0.1692540461 |
| GSE28863_A1 | Down | -0.2026577389 |
| GSE28863_A2 | Up | 0.1044955905 |
| GSE28863_A3 | Down | -0.1637068229 |
| GSE28863_A4 | Down | -0.2839340607 |
| GSE48662 | Up | 0.3158332759 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT001425 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT001425 | Luciferase reporter assay | Functional MTI | 22835829 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT001425 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-15a-5p | MIMAT0000068 | MIRT006998 | Luciferase reporter assay | Functional MTI | 22835829 |
| hsa-miR-15b-5p | MIMAT0000417 | MIRT007001 | Luciferase reporter assay | Functional MTI | 22835829 |
| hsa-miR-20a-5p | MIMAT0000075 | MIRT007002 | Luciferase reporter assay | Functional MTI | 22835829 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT007003 | Luciferase reporter assay | Functional MTI | 22835829 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT007004 | Luciferase reporter assay | Functional MTI | 22835829 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026791 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-103a-3p | MIMAT0000101 | MIRT027227 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT031011 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-484 | MIMAT0002174 | MIRT042016 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
