HCSGD entry for BAX

1. General information

Official gene symbolBAX
Entrez ID581
Gene full nameBCL2-associated X protein
Other gene symbolsBCL2L4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001101Response to acidIEAbiological_process
GO:0001541Ovarian follicle developmentIEAbiological_process
GO:0001764Neuron migrationIEAbiological_process
GO:0001777T cell homeostatic proliferationIEAbiological_process
GO:0001782B cell homeostasisIEAbiological_process
GO:0001783B cell apoptotic processIDAbiological_process
GO:0001822Kidney developmentIEAbiological_process
GO:0001836Release of cytochrome c from mitochondriaIDAbiological_process
GO:0001844Protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayIEAbiological_process
GO:0001974Blood vessel remodelingIEAbiological_process
GO:0002262Myeloid cell homeostasisIEAbiological_process
GO:0002352B cell negative selectionIEAbiological_process
GO:0002358B cell homeostatic proliferationIEAbiological_process
GO:0002904Positive regulation of B cell apoptotic processIEAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIMPcellular_component
GO:0005739MitochondrionIDAcellular_component
GO:0005741Mitochondrial outer membraneIBA TAScellular_component
GO:0005757Mitochondrial permeability transition pore complexIDAcellular_component
GO:0005783Endoplasmic reticulumIDAcellular_component
GO:0005789Endoplasmic reticulum membraneIDAcellular_component
GO:0005829CytosolIDA TAScellular_component
GO:0006687Glycosphingolipid metabolic processIEAbiological_process
GO:0006808Regulation of nitrogen utilizationIEAbiological_process
GO:0006915Apoptotic processNAS TASbiological_process
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processIDA IMPbiological_process
GO:0006927Transformed cell apoptotic processIMPbiological_process
GO:0007281Germ cell developmentIEAbiological_process
GO:0008053Mitochondrial fusionIDAbiological_process
GO:0008289Lipid bindingIDAmolecular_function
GO:0008625Extrinsic apoptotic signaling pathway via death domain receptorsIEAbiological_process
GO:0008630Intrinsic apoptotic signaling pathway in response to DNA damageIBAbiological_process
GO:0008635Activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome cIDAbiological_process
GO:0008637Apoptotic mitochondrial changesIDAbiological_process
GO:0009566FertilizationIEAbiological_process
GO:0009636Response to toxic substanceIDAbiological_process
GO:0009651Response to salt stressIEAbiological_process
GO:0010248Establishment or maintenance of transmembrane electrochemical gradientIDAbiological_process
GO:0010332Response to gamma radiationIEAbiological_process
GO:0015267Channel activityIDAmolecular_function
GO:0016032Viral processIEAbiological_process
GO:0021854Hypothalamus developmentIEAbiological_process
GO:0021987Cerebral cortex developmentIEAbiological_process
GO:0030264Nuclear fragmentation involved in apoptotic nuclear changeIEAbiological_process
GO:0032091Negative regulation of protein bindingIDAbiological_process
GO:0032461Positive regulation of protein oligomerizationIDAbiological_process
GO:0032469Endoplasmic reticulum calcium ion homeostasisTASbiological_process
GO:0032471Negative regulation of endoplasmic reticulum calcium ion concentrationIEAbiological_process
GO:0032976Release of matrix enzymes from mitochondriaIDAbiological_process
GO:0033137Negative regulation of peptidyl-serine phosphorylationIEAbiological_process
GO:0033599Regulation of mammary gland epithelial cell proliferationIEAbiological_process
GO:0034644Cellular response to UVIEAbiological_process
GO:0035234Ectopic germ cell programmed cell deathIEAbiological_process
GO:0042475Odontogenesis of dentin-containing toothIEAbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0042803Protein homodimerization activityIDA IPImolecular_function
GO:0043065Positive regulation of apoptotic processIEA IMPbiological_process
GO:0043496Regulation of protein homodimerization activityIDAbiological_process
GO:0043497Regulation of protein heterodimerization activityIPIbiological_process
GO:0043524Negative regulation of neuron apoptotic processIEAbiological_process
GO:0043525Positive regulation of neuron apoptotic processIDAbiological_process
GO:0043653Mitochondrial fragmentation involved in apoptotic processIDAbiological_process
GO:0045136Development of secondary sexual characteristicsIEAbiological_process
GO:0046666Retinal cell programmed cell deathIEAbiological_process
GO:0046930Pore complexIDAcellular_component
GO:0046982Protein heterodimerization activityIPImolecular_function
GO:0048087Positive regulation of developmental pigmentationIEAbiological_process
GO:0048147Negative regulation of fibroblast proliferationIEAbiological_process
GO:0048515Spermatid differentiationIEAbiological_process
GO:0048597Post-embryonic camera-type eye morphogenesisIEAbiological_process
GO:0048678Response to axon injuryIEAbiological_process
GO:0048873Homeostasis of number of cells within a tissueIEAbiological_process
GO:0051259Protein oligomerizationIDAbiological_process
GO:0051260Protein homooligomerizationIDAbiological_process
GO:0051281Positive regulation of release of sequestered calcium ion into cytosolIEAbiological_process
GO:0051402Neuron apoptotic processIEAbiological_process
GO:0051434BH3 domain bindingIDA IPImolecular_function
GO:0051726Regulation of cell cycleIEAbiological_process
GO:0051881Regulation of mitochondrial membrane potentialIDAbiological_process
GO:0060011Sertoli cell proliferationIEAbiological_process
GO:0060041Retina development in camera-type eyeIEAbiological_process
GO:0060058Positive regulation of apoptotic process involved in mammary gland involutionIEAbiological_process
GO:0060068Vagina developmentIEAbiological_process
GO:0070059Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressIMPbiological_process
GO:0070242Thymocyte apoptotic processIEAbiological_process
GO:0071310Cellular response to organic substanceIEAbiological_process
GO:0072332Intrinsic apoptotic signaling pathway by p53 class mediatorIEAbiological_process
GO:0090200Positive regulation of release of cytochrome c from mitochondriaIDAbiological_process
GO:0097136Bcl-2 family protein complexIDAcellular_component
GO:0097144BAX complexIDAcellular_component
GO:0097190Apoptotic signaling pathwayIDAbiological_process
GO:0097191Extrinsic apoptotic signaling pathwayIDAbiological_process
GO:0097192Extrinsic apoptotic signaling pathway in absence of ligandIBAbiological_process
GO:0097193Intrinsic apoptotic signaling pathwayIDA TASbiological_process
GO:0097296Activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwayIEAbiological_process
GO:1900103Positive regulation of endoplasmic reticulum unfolded protein responseIMPbiological_process
GO:1901030Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwayTASbiological_process
GO:1902262Apoptotic process involved in patterning of blood vesselsIEAbiological_process
GO:1902263Apoptotic process involved in embryonic digit morphogenesisIEAbiological_process
GO:1902512Positive regulation of apoptotic DNA fragmentationIMPbiological_process
GO:1990009Retinal cell apoptotic processIMPbiological_process
GO:1990117B cell receptor apoptotic signaling pathwayIDAbiological_process
GO:2001234Negative regulation of apoptotic signaling pathwayIEAbiological_process
GO:2001241Positive regulation of extrinsic apoptotic signaling pathway in absence of ligandIEAbiological_process
GO:2001244Positive regulation of intrinsic apoptotic signaling pathwayIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.41213230880.03425274500.99999024730.3497154771

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0712517210
GSE13712_SHEARDown-0.1073988010
GSE13712_STATICDown-0.0393270363
GSE19018Up0.4512312525
GSE19899_A1Down-1.2026549693
GSE19899_A2Up0.0538878366
PubMed_21979375_A1Down-0.4805003453
PubMed_21979375_A2Down-0.6332741730
GSE35957Up0.2629590522
GSE36640Down-0.2705787142
GSE54402Down-0.1092989153
GSE9593Up0.2151258328
GSE43922Down-0.0308259184
GSE24585Down-0.0296596286
GSE37065Down-0.1001329504
GSE28863_A1Down-0.3635877954
GSE28863_A2Down-0.7764464160
GSE28863_A3Down-0.2313569871
GSE28863_A4Up0.3426382268
GSE48662Up0.5557600637

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-504-5pMIMAT0002875MIRT016249qRT-PCRNon-Functional MTI (Weak)20542001
hsa-miR-148b-3pMIMAT0000759MIRT019436MicroarrayFunctional MTI (Weak)17612493
hsa-miR-122-5pMIMAT0000421MIRT023402MicroarrayFunctional MTI (Weak)17612493
hsa-miR-122-5pMIMAT0000421MIRT023402Western blotFunctional MTI18692484
hsa-miR-1MIMAT0000416MIRT023989Proteomics;MicroarrayFunctional MTI (Weak)18668037
hsa-miR-30a-5pMIMAT0000087MIRT028651ProteomicsFunctional MTI (Weak)18668040
hsa-miR-365a-3pMIMAT0000710MIRT044018CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-296-5pMIMAT0000690NAhsa-miR-296-5p{Western blot}{downregulation}20485139
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.