HCSGD entry for PTS
1. General information
| Official gene symbol | PTS |
|---|---|
| Entrez ID | 5805 |
| Gene full name | 6-pyruvoyltetrahydropterin synthase |
| Other gene symbols | PTPS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003874 | 6-pyruvoyltetrahydropterin synthase activity | IEA TAS | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006520 | Cellular amino acid metabolic process | TAS | biological_process |
| GO:0006729 | Tetrahydrobiopterin biosynthetic process | IEA | biological_process |
| GO:0007417 | Central nervous system development | TAS | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0042803 | Protein homodimerization activity | IEA | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046209 | Nitric oxide metabolic process | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0050999 | Regulation of nitric-oxide synthase activity | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0420948368 | 0.9585441207 | 0.4586331126 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4926679096 |
| GSE13712_SHEAR | Up | 0.2456096857 |
| GSE13712_STATIC | Up | 0.0880391957 |
| GSE19018 | Down | -0.1882367706 |
| GSE19899_A1 | Up | 0.1431847132 |
| GSE19899_A2 | Up | 0.1998196607 |
| PubMed_21979375_A1 | Up | 0.3773846415 |
| PubMed_21979375_A2 | Up | 0.5933295095 |
| GSE35957 | Up | 0.1457814046 |
| GSE36640 | Up | 0.3559111636 |
| GSE54402 | Up | 0.2599059650 |
| GSE9593 | Down | -0.0761060603 |
| GSE43922 | Up | 0.3400197149 |
| GSE24585 | Down | -0.1214127868 |
| GSE37065 | Down | -0.0487985157 |
| GSE28863_A1 | Up | 0.0348785784 |
| GSE28863_A2 | Up | 0.3424618237 |
| GSE28863_A3 | Down | -0.0476116304 |
| GSE28863_A4 | Up | 0.3136465378 |
| GSE48662 | Down | -0.1790142117 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Biopterin | DB03886 | EXPT00708 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-215-5p | MIMAT0000272 | MIRT024591 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026112 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049542 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 20654685 | We identify the peak times (PTs) of two key proteins as the in silico biomarkers based on the currently established biology, and the results from the local and global sensitivity analyses show the significant kinetic parameters that are associated with the key proteins |
| 16688935 | Although senescent myoblasts display increased level of phosphotyrosine phosphatases (PTPs), neither the PDGF receptor (PDGF-r) phosphorylation level nor the citosolic signal transduction machinery is affected |
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