HCSGD entry for ACTA1

1. General information

Official gene symbolACTA1
Entrez ID58
Gene full nameactin, alpha 1, skeletal muscle
Other gene symbolsACTA ASMA CFTD CFTD1 CFTDM MPFD NEM1 NEM2 NEM3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001725Stress fiberIDAcellular_component
GO:0005200Structural constituent of cytoskeletonTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEA TASmolecular_function
GO:0005737CytoplasmIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005856CytoskeletonIEAcellular_component
GO:0005865Striated muscle thin filamentIDAcellular_component
GO:0005884Actin filamentIDAcellular_component
GO:0006936Muscle contractionTASbiological_process
GO:0009612Response to mechanical stimulusIEAbiological_process
GO:0009991Response to extracellular stimulusIEAbiological_process
GO:0010226Response to lithium ionIEAbiological_process
GO:0015629Actin cytoskeletonIMPcellular_component
GO:0016049Cell growthIEAbiological_process
GO:0017022Myosin bindingTASmolecular_function
GO:0030017SarcomereIDAcellular_component
GO:0030049Muscle filament slidingTASbiological_process
GO:0030240Skeletal muscle thin filament assemblyIMPbiological_process
GO:0043503Skeletal muscle fiber adaptationIEAbiological_process
GO:0043531ADP bindingTASmolecular_function
GO:0048545Response to steroid hormoneIEAbiological_process
GO:0048741Skeletal muscle fiber developmentISSbiological_process
GO:0070062Extracellular vesicular exosomeIDAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.93279446450.15188696860.99999024730.7523436771

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.5025461741
GSE13712_SHEARUp0.1923754187
GSE13712_STATICDown-0.0852690195
GSE19018Down-0.2590645054
GSE19899_A1Down-0.2543383278
GSE19899_A2Up0.1554878985
PubMed_21979375_A1Down-0.3463549671
PubMed_21979375_A2Down-0.0637133105
GSE35957Down-0.0046580346
GSE36640Up0.1565843972
GSE54402Down-0.0938927251
GSE9593Up0.2605672460
GSE43922Down-0.0155970183
GSE24585Down-0.1135474614
GSE37065Down-0.3262124523
GSE28863_A1Down-0.0925309592
GSE28863_A2Down-0.1252498461
GSE28863_A3Up0.2726713224
GSE28863_A4Down-0.0445244369
GSE48662Down-0.0269417935

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Latrunculin ADB02621 EXPT02004
SucroseDB02772 EXPT02977
Ulapualide ADB03021 EXPT03182
Kabiramide CDB03616 EXPT01959
Jaspisamide ADB03850 EXPT01955
TmrDB03903 EXPT02780
4-Methyl-HistidineDB04151 EXPT01748
Phosphoaminophosphonic Acid-Adenylate EsterDB04395 EXPT00524
Aplyronine ADB04629 -
Reidispongiolide ADB04774 -
Reidispongiolide CDB04775 -
Sphinxolide BDB04783 -
LATRUNCULIN BDB08080 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT023513ProteomicsFunctional MTI (Weak)18668040
hsa-miR-877-5pMIMAT0004949MIRT037359CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 6 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26399448In this study, we show that primary cultures of fibroblasts derived from lung biopsies of IPF patients exhibited (i) accelerated replicative cellular senescence (CS); (ii) high resistance to oxidative-stress-induced cytotoxicity or CS; (iii) a CS-like morphology (even at the proliferative phase); and (iv) rapid accumulation of senescent cells expressing the myofibroblast marker alpha-SMA
23719597In primary PSC, doxorubicin treatment was associated with increased expression of interleukin-6 (IL-6) and matrix metalloproteinase (MMP)-9, while expression of the activation marker alpha-smooth muscle actin (alpha-SMA), p53, Cdk1 and Rad54 was diminished
23274627Comparison of TER, alpha-SMA and SA-beta-Gal between CAPD durations suggests that cell polarity weakens with increased duration of CAPD, reflecting the occurrence of EMT and cell senescence
20720180Indoxyl sulfate inhibited serum-induced cell proliferation and promoted the activation of senescence-associated beta-galactosidase, a marker of cellular senescence, and the expression of alpha-smooth muscle actin (alpha-SMA), a marker of fibrosis, through inducing p53 expression and phosphorylation
20720180Indoxyl sulfate evoked reactive oxygen species (ROS), and the antioxidant N-acetylcysteine inhibited indoxyl sulfate-induced p53 expression and phosphorylation, as well as indoxyl sulfate-induced alpha-SMA expression
20585577The SCP cells produced CD24+ or ER+ luminal-like and ASMA+ myoepithelial-like progeny, in addition to CD44+ stem/progenitor-like cells
11344338Exposure of the MK/T-1 cells to TGF-beta induces the expression of smooth muscle alpha-actin (ASMA), the activation of MAP Kinase (p38-MAPK) and morphological changes consistent with cytoskeletal reorganization
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