HCSGD entry for PTPRN
1. General information
| Official gene symbol | PTPRN |
|---|---|
| Entrez ID | 5798 |
| Gene full name | protein tyrosine phosphatase, receptor type, N |
| Other gene symbols | IA-2 IA-2/PTP IA2 ICA512 R-PTP-N |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000302 | Response to reactive oxygen species | IDA | biological_process |
| GO:0004725 | Protein tyrosine phosphatase activity | IEA | molecular_function |
| GO:0005001 | Transmembrane receptor protein tyrosine phosphatase activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0009749 | Response to glucose | IEA | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0019221 | Cytokine-mediated signaling pathway | IEA | biological_process |
| GO:0030507 | Spectrin binding | IPI | molecular_function |
| GO:0032868 | Response to insulin | IEA | biological_process |
| GO:0035335 | Peptidyl-tyrosine dephosphorylation | TAS | biological_process |
| GO:0043627 | Response to estrogen | IEA | biological_process |
| GO:0051020 | GTPase binding | IEA | molecular_function |
| GO:0051591 | Response to cAMP | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2078572471 | 0.1933958892 | 0.8790184126 | 0.8525160275 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2031810373 |
| GSE13712_SHEAR | Up | 0.1664369442 |
| GSE13712_STATIC | Down | -0.1282311935 |
| GSE19018 | Up | 0.0275966860 |
| GSE19899_A1 | Down | -0.3362125946 |
| GSE19899_A2 | Up | 0.4737018090 |
| PubMed_21979375_A1 | Up | 0.6286954825 |
| PubMed_21979375_A2 | Up | 0.5611362963 |
| GSE35957 | Down | -0.0678682246 |
| GSE36640 | Down | -0.6797814844 |
| GSE54402 | Up | 0.0724306052 |
| GSE9593 | Down | -0.5809277764 |
| GSE43922 | Up | 0.3719853771 |
| GSE24585 | Up | 0.1519589881 |
| GSE37065 | Down | -0.2094485499 |
| GSE28863_A1 | Down | -0.1115156400 |
| GSE28863_A2 | Up | 0.1485529504 |
| GSE28863_A3 | Up | 0.4069708644 |
| GSE28863_A4 | Down | -0.6586831642 |
| GSE48662 | Up | 0.0857303684 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040943 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
