HCSGD entry for PTPRC

1. General information

Official gene symbolPTPRC
Entrez ID5788
Gene full nameprotein tyrosine phosphatase, receptor type, C
Other gene symbolsB220 CD45 CD45R GP180 L-CA LCA LY5 T200
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000187Activation of MAPK activityIEAbiological_process
GO:0001915Negative regulation of T cell mediated cytotoxicityIEA ISSbiological_process
GO:0001916Positive regulation of T cell mediated cytotoxicityIEAbiological_process
GO:0001960Negative regulation of cytokine-mediated signaling pathwayIEA ISSbiological_process
GO:0002244Hematopoietic progenitor cell differentiationIMPbiological_process
GO:0002378Immunoglobulin biosynthetic processIMPbiological_process
GO:0002925Positive regulation of humoral immune response mediated by circulating immunoglobulinIEAbiological_process
GO:0004725Protein tyrosine phosphatase activityIDA IEAmolecular_function
GO:0005001Transmembrane receptor protein tyrosine phosphatase activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneIEA ISScellular_component
GO:0005925Focal adhesionIEA ISScellular_component
GO:0006469Negative regulation of protein kinase activityIDA ISSbiological_process
GO:0006470Protein dephosphorylationIEA ISSbiological_process
GO:0006933Negative regulation of cell adhesion involved in substrate-bound cell migrationIMPbiological_process
GO:0007159Leukocyte cell-cell adhesionIEAbiological_process
GO:0007166Cell surface receptor signaling pathwayTASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0008201Heparin bindingIEAmolecular_function
GO:0009897External side of plasma membraneIDA IEAcellular_component
GO:0010332Response to gamma radiationIEAbiological_process
GO:0016311DephosphorylationISSbiological_process
GO:0019901Protein kinase bindingIPImolecular_function
GO:0030183B cell differentiationIEAbiological_process
GO:0030217T cell differentiationISSbiological_process
GO:0030890Positive regulation of B cell proliferationIEA IMPbiological_process
GO:0031953Negative regulation of protein autophosphorylationIEAbiological_process
GO:0034113Heterotypic cell-cell adhesionIEAbiological_process
GO:0035335Peptidyl-tyrosine dephosphorylationIDA TASbiological_process
GO:0042098T cell proliferationIEAbiological_process
GO:0042100B cell proliferationIEA ISSbiological_process
GO:0042102Positive regulation of T cell proliferationISSbiological_process
GO:0043395Heparan sulfate proteoglycan bindingIEAmolecular_function
GO:0044770Cell cycle phase transitionIMPbiological_process
GO:0045059Positive thymic T cell selectionIEAbiological_process
GO:0045060Negative thymic T cell selectionIEAbiological_process
GO:0045121Membrane raftIEAcellular_component
GO:0045577Regulation of B cell differentiationIEAbiological_process
GO:0045588Positive regulation of gamma-delta T cell differentiationIEAbiological_process
GO:0045860Positive regulation of protein kinase activityNASbiological_process
GO:0046641Positive regulation of alpha-beta T cell proliferationIEAbiological_process
GO:0048304Positive regulation of isotype switching to IgG isotypesIEAbiological_process
GO:0048539Bone marrow developmentIMPbiological_process
GO:0048864Stem cell developmentIMPbiological_process
GO:0050732Negative regulation of peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0050852T cell receptor signaling pathwayIDA IEA TASbiological_process
GO:0050853B cell receptor signaling pathwayIEA ISSbiological_process
GO:0050855Regulation of B cell receptor signaling pathwayIEAbiological_process
GO:0050857Positive regulation of antigen receptor-mediated signaling pathwayIEA ISSbiological_process
GO:0051209Release of sequestered calcium ion into cytosolIEA ISSbiological_process
GO:0051607Defense response to virusIEA ISSbiological_process
GO:0051726Regulation of cell cycleIEA ISSbiological_process
GO:2000473Positive regulation of hematopoietic stem cell migrationIMPbiological_process
GO:2000648Positive regulation of stem cell proliferationIMPbiological_process
GO:2001238Positive regulation of extrinsic apoptotic signaling pathwayIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.72998463580.39755025260.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1997264924
GSE13712_SHEARDown-0.0371763265
GSE13712_STATICDown-0.1078454558
GSE19018Up0.1100719216
GSE19899_A1Up0.0123701339
GSE19899_A2Up0.0501791904
PubMed_21979375_A1Up0.0876108273
PubMed_21979375_A2Up0.1981199891
GSE35957Up0.0183092263
GSE36640Up0.0378852444
GSE54402Up0.4278760433
GSE9593Down-0.0468103900
GSE43922Up0.0194052339
GSE24585Up0.0796226940
GSE37065Up0.0193557600
GSE28863_A1Down-0.7249662109
GSE28863_A2Down-0.5613918755
GSE28863_A3Down-0.0613969690
GSE28863_A4Down-0.0557705648
GSE48662Up0.0041487296

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 9 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

275790451, CD44H, CD29, and CD71 and lack of CD11b/c and CD45 markers
26196672All cells were negative for leukocyte markers (CD19, CD34, CD45) and CD73 positive
25892207Microglia in TERC KO mice maintained a homogenous distribution and normal expression of CD45 and CD68 and the aging marker, ferritin, but were morphologically distinct from microglia in both adult and old wild-type mice
25057108Isolation of a circulating CD45-, CD34dim cell population and validation of their endothelial phenotype
25057108Here, a CEC population in healthy adult human subjects was identified by flow cytometry as CD45-, CD34dim that is comparable to a previously described CD45-, CD31bright population
25057108Unexpectedly, the CD45-, CD34dim, 7-AAD- CECs lacked surface detectable CD146, a commonly used marker of CECs
25057108Thus the majority of CECs in healthy individuals as defined by CD45-, CD34dim, and 7-AAD- have shed their CD146 surface marker and are senescent cells without an identifiable nucleus and lacking RNA of sufficient quantity and quality for transcriptomal analysis
241703702%, respectively; all cells were negative for CD11b, CD19, and CD45
23106472The cells harvested by both methods gave positive results for CD44 and CD90 and negative results for CD34 and CD45
22721583Both PB-MSCs and BM-MSCs were positive for CD44 and CD90, and negative for CD34 and CD45
21176525RESULTS: Flow cytometry results showed the detection rates for CD29, CD34 and CD45 were 97
20132052FACS analysis confirmed expression of the stem cell markers CD44, CD90, CD105, and CD166, but negative expression of CD34 and CD45 ruling out a hematopoietic or fibrocyte origin for these progenitors
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