HCSGD entry for PTPRA
1. General information
| Official gene symbol | PTPRA |
|---|---|
| Entrez ID | 5786 |
| Gene full name | protein tyrosine phosphatase, receptor type, A |
| Other gene symbols | HEPTP HLPR HPTPA HPTPalpha LRP PTPA PTPRL2 R-PTP-alpha RPTPA |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004725 | Protein tyrosine phosphatase activity | IEA TAS | molecular_function |
| GO:0005001 | Transmembrane receptor protein tyrosine phosphatase activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006468 | Protein phosphorylation | IEA | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0008286 | Insulin receptor signaling pathway | IEA | biological_process |
| GO:0035335 | Peptidyl-tyrosine dephosphorylation | TAS | biological_process |
| GO:0043235 | Receptor complex | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1345819916 | 0.9281855629 | 0.7433389597 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0722132623 |
| GSE13712_SHEAR | Down | -0.1961429653 |
| GSE13712_STATIC | Up | 0.0519604918 |
| GSE19018 | Up | 0.1459702683 |
| GSE19899_A1 | Down | -0.1977464651 |
| GSE19899_A2 | Up | 0.6534746013 |
| PubMed_21979375_A1 | Up | 0.0969631818 |
| PubMed_21979375_A2 | Up | 0.2761101758 |
| GSE35957 | Up | 0.2959345965 |
| GSE36640 | Up | 0.6898481929 |
| GSE54402 | Down | -0.2434399061 |
| GSE9593 | Up | 0.3907993658 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Up | 0.3291488872 |
| GSE28863_A2 | Up | 0.1556636693 |
| GSE28863_A3 | Down | -0.2256661357 |
| GSE28863_A4 | Up | 0.0182616906 |
| GSE48662 | Up | 0.3106620936 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017376 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 14499637 | Concomitantly, we also discovered an increase in expression of receptor protein tyrosine phosphatase alpha (RPTPalpha) |
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