HCSGD entry for PTPN6

1. General information

Official gene symbolPTPN6
Entrez ID5777
Gene full nameprotein tyrosine phosphatase, non-receptor type 6
Other gene symbolsHCP HCPH HPTP1C PTP-1C SH-PTP1 SHP-1 SHP-1L SHP1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001784Phosphotyrosine bindingIEAmolecular_function
GO:0002924Negative regulation of humoral immune response mediated by circulating immunoglobulinIEAbiological_process
GO:0004725Protein tyrosine phosphatase activityIEA TASmolecular_function
GO:0005001Transmembrane receptor protein tyrosine phosphatase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006470Protein dephosphorylationIDAbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008283Cell proliferationIDAbiological_process
GO:0008284Positive regulation of cell proliferationIMPbiological_process
GO:0008285Negative regulation of cell proliferationNASbiological_process
GO:0014068Positive regulation of phosphatidylinositol 3-kinase signalingIMPbiological_process
GO:0016020MembraneTAScellular_component
GO:0017124SH3 domain bindingIEAmolecular_function
GO:0018108Peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0019221Cytokine-mediated signaling pathwayTASbiological_process
GO:0019901Protein kinase bindingIPImolecular_function
GO:0030154Cell differentiationIDAbiological_process
GO:0031295T cell costimulationTASbiological_process
GO:0035556Intracellular signal transductionIEAbiological_process
GO:0042105Alpha-beta T cell receptor complexIEAcellular_component
GO:0042130Negative regulation of T cell proliferationIEAbiological_process
GO:0042169SH2 domain bindingIEAmolecular_function
GO:0042267Natural killer cell mediated cytotoxicityIEAbiological_process
GO:0043407Negative regulation of MAP kinase activityIEAbiological_process
GO:0045577Regulation of B cell differentiationIEAbiological_process
GO:0050732Negative regulation of peptidyl-tyrosine phosphorylationIEA IMPbiological_process
GO:0050853B cell receptor signaling pathwayIEAbiological_process
GO:0050860Negative regulation of T cell receptor signaling pathwayIEAbiological_process
GO:0050900Leukocyte migrationTASbiological_process
GO:0060333Interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0060334Regulation of interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0060337Type I interferon signaling pathwayTASbiological_process
GO:0060338Regulation of type I interferon-mediated signaling pathwayTASbiological_process
GO:0060397JAK-STAT cascade involved in growth hormone signaling pathwayTASbiological_process
GO:0070372Regulation of ERK1 and ERK2 cascadeIDAbiological_process
GO:2000045Regulation of G1/S transition of mitotic cell cycleIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.38206850420.41836842070.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0287024403
GSE13712_SHEARDown-0.2862124607
GSE13712_STATICDown-0.0878982615
GSE19018Up0.0633772336
GSE19899_A1Up0.0448086597
GSE19899_A2Up0.0577667061
PubMed_21979375_A1Up0.0707942628
PubMed_21979375_A2Down-0.0183597788
GSE35957Up0.0803252709
GSE36640Up0.0035329423
GSE54402Up0.1276739838
GSE9593Down-0.0160226511
GSE43922Up0.0794471247
GSE24585Up0.6806368437
GSE37065Down-0.0470091187
GSE28863_A1Down-0.5597649636
GSE28863_A2Down-0.7301611747
GSE28863_A3Up0.3272616875
GSE28863_A4Up0.1996730333
GSE48662Up0.1337597150

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26215037Increased SHP-1 expression results in radioresistance, inhibition of cellular senescence, and cell cycle redistribution in nasopharyngeal carcinoma cells
26215037SHP-1 is involved in cancer progression, but its role in radioresistance and senescence of NPC is not well understood
26215037This study aimed to assess the role of SHP-1 in the radioresistance and senescence of NPC cells
26215037METHODS: SHP-1 was knocked-down and overexpressed in CNE-1 and CNE-2 cells using lentiviruses
26215037Western blot was used to assess SHP-1, p21, p53, pRb, Rb, H3K9Me3, HP1gamma, CDK4, cyclin D1, cyclin E, and p16 protein expressions
26215037RESULTS: Compared with CNE-1-scramble shRNA cells, SHP-1 downregulation resulted in increased senescence (+107%, P < 0
26215037Furthermore, SHP-1 overexpression resulted in radioresistance, inhibition of cellular senescence, and cell cycle arrest in the S phase
26215037CONCLUSION: SHP-1 has a critical role in radioresistance, cell cycle progression, and senescence of NPC cells
26215037Down-regulating SHP-1 may be a promising therapeutic approach for treating patients with NPC
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