HCSGD entry for PTPN3
1. General information
| Official gene symbol | PTPN3 |
|---|---|
| Entrez ID | 5774 |
| Gene full name | protein tyrosine phosphatase, non-receptor type 3 |
| Other gene symbols | PTP-H1 PTPH1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001784 | Phosphotyrosine binding | IPI | molecular_function |
| GO:0004725 | Protein tyrosine phosphatase activity | IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005856 | Cytoskeleton | IEA | cellular_component |
| GO:0006470 | Protein dephosphorylation | IDA | biological_process |
| GO:0008092 | Cytoskeletal protein binding | IEA | molecular_function |
| GO:0009898 | Cytoplasmic side of plasma membrane | IDA | cellular_component |
| GO:0035335 | Peptidyl-tyrosine dephosphorylation | IDA TAS | biological_process |
| GO:0045930 | Negative regulation of mitotic cell cycle | IDA | biological_process |
| GO:0051045 | Negative regulation of membrane protein ectodomain proteolysis | IMP | biological_process |
| GO:0051117 | ATPase binding | IPI | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2167592417 | 0.6148938376 | 0.8956794795 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0448650697 |
| GSE13712_SHEAR | Up | 0.0991224917 |
| GSE13712_STATIC | Down | -0.0331565239 |
| GSE19018 | Up | 0.3977370080 |
| GSE19899_A1 | Up | 0.1616359114 |
| GSE19899_A2 | Up | 0.3627012438 |
| PubMed_21979375_A1 | Up | 0.4014495786 |
| PubMed_21979375_A2 | Down | -0.0875501180 |
| GSE35957 | Down | -0.4615614508 |
| GSE36640 | Down | -1.1469288551 |
| GSE54402 | Up | 0.5096805623 |
| GSE9593 | Up | 0.0711718045 |
| GSE43922 | Up | 0.0236960001 |
| GSE24585 | Down | -0.1303489493 |
| GSE37065 | Up | 0.0426281170 |
| GSE28863_A1 | Down | -0.1089772787 |
| GSE28863_A2 | Down | -0.1600400170 |
| GSE28863_A3 | Up | 0.4125040789 |
| GSE28863_A4 | Up | 0.0885358493 |
| GSE48662 | Down | -0.2113296965 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-103a-3p | MIMAT0000101 | MIRT027192 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT031028 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT032073 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
