HCSGD entry for PREX1

1. General information

Official gene symbolPREX1
Entrez ID57580
Gene full namephosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
Other gene symbolsP-REX1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005089Rho guanyl-nucleotide exchange factor activityTASmolecular_function
GO:0005100Rho GTPase activator activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005543Phospholipid bindingIDAmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolIDAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006801Superoxide metabolic processTASbiological_process
GO:0019899Enzyme bindingTASmolecular_function
GO:0030041Actin filament polymerizationTASbiological_process
GO:0030426Growth coneIEAcellular_component
GO:0030833Regulation of actin filament polymerizationIEAbiological_process
GO:0032318Regulation of Ras GTPase activityTASbiological_process
GO:0032319Regulation of Rho GTPase activityTASbiological_process
GO:0032320Positive regulation of Ras GTPase activityTASbiological_process
GO:0032321Positive regulation of Rho GTPase activityTASbiological_process
GO:0035556Intracellular signal transductionIEAbiological_process
GO:0042119Neutrophil activationTASbiological_process
GO:0043085Positive regulation of catalytic activityTASbiological_process
GO:0043087Regulation of GTPase activityTASbiological_process
GO:0043198Dendritic shaftIEAcellular_component
GO:0043231Intracellular membrane-bounded organelleIDAcellular_component
GO:0043547Positive regulation of GTPase activityTASbiological_process
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
GO:0050773Regulation of dendrite developmentIEAbiological_process
GO:0050790Regulation of catalytic activityTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00082384410.88864901790.07972205881.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.6258433067
GSE13712_SHEARDown-0.1189566439
GSE13712_STATICDown-0.1884131608
GSE19018Down-0.1245481176
GSE19899_A1Up0.5734837629
GSE19899_A2Up3.1765478195
PubMed_21979375_A1Up2.2343861555
PubMed_21979375_A2Up2.2327118553
GSE35957Down-1.1699309914
GSE36640Down-0.1085217156
GSE54402Up2.5153127244
GSE9593Up0.4940487729
GSE43922Up2.1918497445
GSE24585Up0.1382020944
GSE37065Up0.4553436900
GSE28863_A1Down-0.0571691965
GSE28863_A2Up0.1365549602
GSE28863_A3Up0.3020450371
GSE28863_A4Up0.1512482138
GSE48662Down-0.1819303096

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT002783Microarray//Microarray;OtherFunctional MTI (Weak)15685193
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-1MIMAT0000416NAhsa-miR-115685193
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.