HCSGD entry for KLHL42
1. General information
| Official gene symbol | KLHL42 |
|---|---|
| Entrez ID | 57542 |
| Gene full name | kelch-like family member 42 |
| Other gene symbols | Ctb9 KLHDC5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000209 | Protein polyubiquitination | IDA | biological_process |
| GO:0004842 | Ubiquitin-protein ligase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005819 | Spindle | IEA | cellular_component |
| GO:0007067 | Mitosis | IEA | biological_process |
| GO:0031463 | Cul3-RING ubiquitin ligase complex | IDA | cellular_component |
| GO:0032886 | Regulation of microtubule-based process | IMP | biological_process |
| GO:0043161 | Proteasome-mediated ubiquitin-dependent protein catabolic process | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8190604498 | 0.1932218799 | 0.9999902473 | 0.8521829759 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4414525434 |
| GSE13712_SHEAR | Up | 0.2270857825 |
| GSE13712_STATIC | Up | 0.1917962331 |
| GSE19018 | Down | -0.7039496223 |
| GSE19899_A1 | Down | -0.0307762378 |
| GSE19899_A2 | Up | 0.0146416060 |
| PubMed_21979375_A1 | Up | 0.2225598745 |
| PubMed_21979375_A2 | Up | 0.1155768581 |
| GSE35957 | Down | -0.0094550002 |
| GSE36640 | Down | -0.3736752488 |
| GSE54402 | Up | 0.2865778283 |
| GSE9593 | Down | -0.2194730458 |
| GSE43922 | Up | 0.0194522231 |
| GSE24585 | Down | -0.0651284639 |
| GSE37065 | Down | -0.0628673256 |
| GSE28863_A1 | Up | 0.1497661791 |
| GSE28863_A2 | Down | -0.0582351473 |
| GSE28863_A3 | Down | -0.0047665767 |
| GSE28863_A4 | Up | 0.0865259410 |
| GSE48662 | Down | -0.4837871864 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT003852 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-1 | MIMAT0000416 | MIRT003852 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT016145 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-340-5p | MIMAT0004692 | MIRT019582 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-181a-5p | MIMAT0000256 | MIRT025204 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026594 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-32-5p | MIMAT0000090 | MIRT028299 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030926 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047964 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
