HCSGD entry for MIB1
1. General information
| Official gene symbol | MIB1 |
|---|---|
| Entrez ID | 57534 |
| Gene full name | mindbomb E3 ubiquitin protein ligase 1 |
| Other gene symbols | DIP-1 DIP1 LVNC7 MIB ZZANK2 ZZZ6 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001568 | Blood vessel development | IEA | biological_process |
| GO:0001701 | In utero embryonic development | IEA | biological_process |
| GO:0001756 | Somitogenesis | IEA | biological_process |
| GO:0001841 | Neural tube formation | IEA | biological_process |
| GO:0001947 | Heart looping | IEA | biological_process |
| GO:0004842 | Ubiquitin-protein ligase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005813 | Centrosome | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0007219 | Notch signaling pathway | TAS | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0014069 | Postsynaptic density | IEA | cellular_component |
| GO:0031410 | Cytoplasmic vesicle | IEA | cellular_component |
| GO:0031965 | Nuclear membrane | IDA | cellular_component |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0045665 | Negative regulation of neuron differentiation | IEA | biological_process |
| GO:0045807 | Positive regulation of endocytosis | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2627337107 | 0.4044700125 | 0.9567040111 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0177848907 |
| GSE13712_SHEAR | Up | 0.0753110488 |
| GSE13712_STATIC | Up | 0.2885394559 |
| GSE19018 | Up | 0.3394346228 |
| GSE19899_A1 | Up | 0.2854376035 |
| GSE19899_A2 | Down | -0.4935932203 |
| PubMed_21979375_A1 | Down | -0.2364325524 |
| PubMed_21979375_A2 | Down | -0.3161289339 |
| GSE35957 | Up | 0.0118460219 |
| GSE36640 | Down | -0.5849548269 |
| GSE54402 | Up | 0.1728428180 |
| GSE9593 | Down | -0.2795634313 |
| GSE43922 | Up | 0.1339518447 |
| GSE24585 | Up | 0.0385605124 |
| GSE37065 | Down | -0.0695625877 |
| GSE28863_A1 | Up | 0.3563225004 |
| GSE28863_A2 | Up | 0.5760769523 |
| GSE28863_A3 | Down | -0.7009199018 |
| GSE28863_A4 | Up | 0.1215632142 |
| GSE48662 | Down | -0.0813351649 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-210-3p | MIMAT0000267 | MIRT003176 | immunoprecipitaion//Microarray//qRT-PCR | Functional MTI (Weak) | 19826008 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024481 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026726 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-103a-3p | MIMAT0000101 | MIRT027205 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030987 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031932 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041392 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052189 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT052585 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 12536228 | MIB-1 immunolabeling of the droplet-bearing cells was almost negative; however, they maintained a viable nuclear appearance without karyorrhexis, pyknosis or apoptotic changes |
| 8685097 | Immunohistochemistry was performed on paraffin-embedded tissue sections using the MIB-1 monoclonal antibody |
| 8685097 | MIB-1 recognizes the proliferation-associated Ki-67 protein which is expressed during the active phases of the cell cycle but cannot be detected in senescent cells |
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