HCSGD entry for HACE1
1. General information
| Official gene symbol | HACE1 |
|---|---|
| Entrez ID | 57531 |
| Gene full name | HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IDA | cellular_component |
| GO:0004842 | Ubiquitin-protein ligase activity | IDA IEA | molecular_function |
| GO:0005634 | Nucleus | IBA | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0007030 | Golgi organization | IDA | biological_process |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0016567 | Protein ubiquitination | IDA | biological_process |
| GO:0016601 | Rac protein signal transduction | TAS | biological_process |
| GO:0017137 | Rab GTPase binding | IDA | molecular_function |
| GO:0030334 | Regulation of cell migration | IMP | biological_process |
| GO:0032580 | Golgi cisterna membrane | IEA | cellular_component |
| GO:0042787 | Protein ubiquitination involved in ubiquitin-dependent protein catabolic process | IDA | biological_process |
| GO:0048365 | Rac GTPase binding | IPI | molecular_function |
| GO:0061025 | Membrane fusion | IMP | biological_process |
| GO:0070936 | Protein K48-linked ubiquitination | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4930328255 | 0.0348835379 | 0.9999902473 | 0.3532780300 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.9827271397 |
| GSE13712_SHEAR | Down | -0.8850918730 |
| GSE13712_STATIC | Down | -0.4113700579 |
| GSE19018 | Up | 0.5677186107 |
| GSE19899_A1 | Up | 0.3443890008 |
| GSE19899_A2 | Down | -0.4401316217 |
| PubMed_21979375_A1 | Down | -0.3078915617 |
| PubMed_21979375_A2 | Down | -0.5532792179 |
| GSE35957 | Up | 0.0477812196 |
| GSE36640 | Up | 0.2034887199 |
| GSE54402 | Up | 0.1374172958 |
| GSE9593 | Down | -0.0341807606 |
| GSE43922 | Up | 0.0349088624 |
| GSE24585 | Up | 0.6302496304 |
| GSE37065 | Down | -0.0865042959 |
| GSE28863_A1 | Down | -0.1038469657 |
| GSE28863_A2 | Up | 0.4151167111 |
| GSE28863_A3 | Down | -0.7105007780 |
| GSE28863_A4 | Down | -0.2834093990 |
| GSE48662 | Down | -0.3006238638 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT000854 | Microarray | Functional MTI (Weak) | 18362358 |
| hsa-miR-15a-5p | MIMAT0000068 | MIRT000855 | Microarray | Functional MTI (Weak) | 18362358 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016517 | Microarray | Functional MTI (Weak) | 20304954 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-15a-5p | MIMAT0000068 | NA | hsa-miR-15a | 18362358 | |||
| hsa-miR-16-5p | MIMAT0000069 | NA | hsa-miR-16 | 18362358 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
