HCSGD entry for AARS2
1. General information
| Official gene symbol | AARS2 |
|---|---|
| Entrez ID | 57505 |
| Gene full name | alanyl-tRNA synthetase 2, mitochondrial |
| Other gene symbols | AARSL COXPD8 MT-ALARS MTALARS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000049 | TRNA binding | IEA | molecular_function |
| GO:0004813 | Alanine-tRNA ligase activity | IMP | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0006418 | TRNA aminoacylation for protein translation | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0033108 | Mitochondrial respiratory chain complex assembly | IMP | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0070143 | Mitochondrial alanyl-tRNA aminoacylation | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5213745184 | 0.6604109722 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1137840995 |
| GSE13712_SHEAR | Down | -0.0986085562 |
| GSE13712_STATIC | Down | -0.0403148919 |
| GSE19018 | Up | 0.2917984468 |
| GSE19899_A1 | Up | 0.0550093495 |
| GSE19899_A2 | Down | -0.1049153683 |
| PubMed_21979375_A1 | Up | 0.2197569619 |
| PubMed_21979375_A2 | Up | 0.3956656481 |
| GSE35957 | Down | -0.1283806086 |
| GSE36640 | Down | -0.2064343897 |
| GSE54402 | Down | -0.0483830383 |
| GSE9593 | Down | -0.4687157876 |
| GSE43922 | Up | 0.0377930770 |
| GSE24585 | Down | -0.1385292967 |
| GSE37065 | Up | 0.0415166493 |
| GSE28863_A1 | Up | 0.1662548638 |
| GSE28863_A2 | Up | 0.3897033651 |
| GSE28863_A3 | Up | 0.0166408068 |
| GSE28863_A4 | Down | -0.0447751861 |
| GSE48662 | Down | -0.0765839413 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| L-Alanine | DB00160 | NUTR00013 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-484 | MIMAT0002174 | MIRT041862 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-378a-5p | MIMAT0000731 | MIRT043972 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23b-3p | MIMAT0000418 | MIRT046318 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049144 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
