HCSGD entry for MKL2
1. General information
| Official gene symbol | MKL2 |
|---|---|
| Entrez ID | 57496 |
| Gene full name | MKL/myocardin-like 2 |
| Other gene symbols | MRTF-B NPD001 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001701 | In utero embryonic development | IEA | biological_process |
| GO:0001889 | Liver development | IEA | biological_process |
| GO:0003007 | Heart morphogenesis | IEA | biological_process |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0003713 | Transcription coactivator activity | IDA | molecular_function |
| GO:0003779 | Actin binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IC | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0007517 | Muscle organ development | IEA | biological_process |
| GO:0010467 | Gene expression | IEA | biological_process |
| GO:0045844 | Positive regulation of striated muscle tissue development | IDA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA IEA | biological_process |
| GO:0048514 | Blood vessel morphogenesis | IEA | biological_process |
| GO:0048568 | Embryonic organ development | IEA | biological_process |
| GO:0048738 | Cardiac muscle tissue development | IEA | biological_process |
| GO:0051145 | Smooth muscle cell differentiation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9501251434 | 0.2008071312 | 0.9999902473 | 0.8666083784 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0232797072 |
| GSE13712_SHEAR | Down | -0.0143143423 |
| GSE13712_STATIC | Down | -0.1155440949 |
| GSE19018 | Down | -0.0915527429 |
| GSE19899_A1 | Up | 0.0516566238 |
| GSE19899_A2 | Down | -0.1704849545 |
| PubMed_21979375_A1 | Down | -0.0344624246 |
| PubMed_21979375_A2 | Down | -0.3703887684 |
| GSE35957 | Up | 0.1654236953 |
| GSE36640 | Down | -0.6281363698 |
| GSE54402 | Up | 0.4229170527 |
| GSE9593 | Down | -0.2423055013 |
| GSE43922 | Down | -0.5323500140 |
| GSE24585 | Down | -0.0375248894 |
| GSE37065 | Down | -0.0420707218 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.1546990584 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-29c-3p | MIMAT0000681 | MIRT020358 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024852 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026812 | Microarray | Functional MTI (Weak) | 19074876 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
