HCSGD entry for NDRG2
1. General information
| Official gene symbol | NDRG2 |
|---|---|
| Entrez ID | 57447 |
| Gene full name | NDRG family member 2 |
| Other gene symbols | SYLD |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001818 | Negative regulation of cytokine production | IEA | biological_process |
| GO:0003674 | Molecular_function | ND | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA IEA | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0005813 | Centrosome | IDA | cellular_component |
| GO:0005829 | Cytosol | NAS | cellular_component |
| GO:0007165 | Signal transduction | IEA | biological_process |
| GO:0007399 | Nervous system development | IEA | biological_process |
| GO:0010574 | Regulation of vascular endothelial growth factor production | IEA | biological_process |
| GO:0016055 | Wnt signaling pathway | IEA | biological_process |
| GO:0030154 | Cell differentiation | IEA | biological_process |
| GO:0030426 | Growth cone | IEA | cellular_component |
| GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0048662 | Negative regulation of smooth muscle cell proliferation | IEA | biological_process |
| GO:0070373 | Negative regulation of ERK1 and ERK2 cascade | IEA | biological_process |
| GO:0090361 | Regulation of platelet-derived growth factor production | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6318706508 | 0.8599347783 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0118570776 |
| GSE13712_SHEAR | Up | 0.0897754070 |
| GSE13712_STATIC | Down | -0.1073216425 |
| GSE19018 | Up | 0.1323773499 |
| GSE19899_A1 | Up | 0.0246658971 |
| GSE19899_A2 | Up | 0.0331666643 |
| PubMed_21979375_A1 | Up | 0.3258067923 |
| PubMed_21979375_A2 | Down | -0.0383083699 |
| GSE35957 | Up | 0.1685942335 |
| GSE36640 | Down | -0.3124684893 |
| GSE54402 | Down | -0.0747030364 |
| GSE9593 | Up | 0.0700860969 |
| GSE43922 | Up | 0.0251549077 |
| GSE24585 | Up | 0.0736428114 |
| GSE37065 | Up | 0.1691274850 |
| GSE28863_A1 | Down | -0.2821227091 |
| GSE28863_A2 | Up | 0.1940106984 |
| GSE28863_A3 | Up | 0.2559875593 |
| GSE28863_A4 | Up | 0.0623041737 |
| GSE48662 | Down | -0.0457946500 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-145-5p | MIMAT0000437 | MIRT021510 | Reporter assay;Microarray | Functional MTI | 21351259 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25701873 | We focused on two of these proteins, NDRG2 and TRIM72, due to their putative roles in myoblast proliferation and myogenesis |
| 25701873 | Follow-up analysis confirmed that both proteins were ubiquitinated by TRIM32 in vitro; however, only NDRG2 accumulated in skeletal muscle and myoblasts in the absence of TRIM32 |
| 25701873 | NDRG2 overexpression in myoblasts led to reduced cell proliferation and delayed cell cycle withdrawal during differentiation |
| 25701873 | Thus, we identified NDRG2 as a novel target for TRIM32; these findings further corroborate the hypothesis that TRIM32 is involved in control of myogenic cells proliferation and differentiation |
| 22043305 | Up-regulation of NDRG2 in senescent lens epithelial cells contributes to age-related cataract in human |
| 22043305 | BACKGROUND: Human N-Myc downstream regulated gene2 (NDRG2), a novel gene has been cloned and shown to be related to a number of cellular processes, including proliferation, differentiation, stress, and apoptosis |
| 22043305 | NDRG2 has also been linked to age-related Alzheimer's disease |
| 22043305 | Since the role of this gene in senescence is limited, we have investigated the potential role of NDRG2 in human lens epithelial cells (HLECs), a paradigm implicated in age-related cataract |
| 22043305 | Ndrg2 protein expression was also significantly increased in these senescent cells |
| 22043305 | To induce overexpression of NDRG2, SRA01/04 cells were infected with the adenoviral vector of NDRG2 |
| 22043305 | In these cells, overexpression of NDRG2 resulted in a fibroblast-like appearance and the cell viability decreased about 20% |
| 22043305 | Furthermore, the expression of NDRG2 from age-related cataracts was up-regulated 2-fold at both mRNA and protein levels compared with the clear lenses |
| 22043305 | CONCLUSIONS/SIGNIFICANCE: NDRG2 is up regulated not only in the ageing process of HLECs in vitro but also in the cells from human age-related cortical cataract in vivo |
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