HCSGD entry for SCYL1
1. General information
| Official gene symbol | SCYL1 |
|---|---|
| Entrez ID | 57410 |
| Gene full name | SCY1-like 1 (S. cerevisiae) |
| Other gene symbols | GKLP NKTL NTKL P105 TAPK TEIF TRAP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0004672 | Protein kinase activity | IEA | molecular_function |
| GO:0004713 | Protein tyrosine kinase activity | NAS | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA ISS | cellular_component |
| GO:0005793 | Endoplasmic reticulum-Golgi intermediate compartment | IDA | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0005801 | Cis-Golgi network | IDA | cellular_component |
| GO:0005815 | Microtubule organizing center | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0006890 | Retrograde vesicle-mediated transport, Golgi to ER | IDA | biological_process |
| GO:0018108 | Peptidyl-tyrosine phosphorylation | NAS | biological_process |
| GO:0030126 | COPI vesicle coat | IDA IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4280388093 | 0.7871331940 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1185471641 |
| GSE13712_SHEAR | Down | -0.2482972793 |
| GSE13712_STATIC | Down | -0.0565616556 |
| GSE19018 | Up | 0.0757401962 |
| GSE19899_A1 | Down | -0.1755925370 |
| GSE19899_A2 | Down | -0.0070961777 |
| PubMed_21979375_A1 | Up | 0.0807201070 |
| PubMed_21979375_A2 | Up | 0.3228969020 |
| GSE35957 | Down | -0.1495983597 |
| GSE36640 | Up | 0.2843227484 |
| GSE54402 | Up | 0.2442819752 |
| GSE9593 | Down | -0.0740057000 |
| GSE43922 | Down | -0.0374862953 |
| GSE24585 | Up | 0.0505214728 |
| GSE37065 | Up | 0.0103229435 |
| GSE28863_A1 | Up | 0.2331986523 |
| GSE28863_A2 | Up | 0.3214353993 |
| GSE28863_A3 | Up | 0.1476848029 |
| GSE28863_A4 | Up | 0.0436803296 |
| GSE48662 | Down | -0.3784059538 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Grn163l | DB05036 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7b-5p | MIMAT0000063 | MIRT001596 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028426 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-484 | MIMAT0002174 | MIRT041975 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT043006 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051600 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24361335 | The 58-kda microspherule protein (MSP58) represses human telomerase reverse transcriptase (hTERT) gene expression and cell proliferation by interacting with telomerase transcriptional element-interacting factor (TEIF) |
| 24361335 | Here we identify telomerase transcriptional element-interacting factor (TEIF) as a novel MSP58-interacting protein and determine the effect of MSP58 on hTERT transcription |
| 24361335 | The inhibitory effect of MSP58 occurred through inhibition of TEIF binding to DNA |
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