HCSGD entry for PTGFR
1. General information
| Official gene symbol | PTGFR |
|---|---|
| Entrez ID | 5737 |
| Gene full name | prostaglandin F receptor (FP) |
| Other gene symbols | FP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004958 | Prostaglandin F receptor activity | IDA IEA | molecular_function |
| GO:0005576 | Extracellular region | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IDA TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0007567 | Parturition | TAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0032496 | Response to lipopolysaccharide | IEA | biological_process |
| GO:0035584 | Calcium-mediated signaling using intracellular calcium source | IDA | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0326783861 | 0.0815305611 | 0.4168364341 | 0.5406835475 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2408736044 |
| GSE13712_SHEAR | Up | 0.7647891270 |
| GSE13712_STATIC | Up | 0.1751121421 |
| GSE19018 | Up | 0.0075293627 |
| GSE19899_A1 | Up | 0.1994712390 |
| GSE19899_A2 | Down | -1.6038592298 |
| PubMed_21979375_A1 | Down | -0.4026568827 |
| PubMed_21979375_A2 | Down | -2.0822229324 |
| GSE35957 | Down | -1.8514600865 |
| GSE36640 | Up | 1.5656410961 |
| GSE54402 | Down | -0.8439697569 |
| GSE9593 | Up | 0.3314244367 |
| GSE43922 | Down | -0.6999211957 |
| GSE24585 | Up | 0.9997688906 |
| GSE37065 | Up | 0.0605752774 |
| GSE28863_A1 | Up | 0.5672757667 |
| GSE28863_A2 | Up | 1.0552561547 |
| GSE28863_A3 | Down | -0.0900536442 |
| GSE28863_A4 | Up | 0.0267345647 |
| GSE48662 | Down | -0.1948374039 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Travoprost | DB00287 | APRD01271 |
| Bimatoprost | DB00905 | APRD00826 | DB06863 |
| Dinoprost Tromethamine | DB01160 | APRD00926 |
| Tafluprost | DB08819 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-21-5p | MIMAT0000076 | MIRT031037 | Microarray | Functional MTI (Weak) | 18591254 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 18971427 | No reduction occurred in the presence of prostaglandin F receptor antagonists in H(2)O(2)-treated cells |
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