HCSGD entry for SENP7
1. General information
| Official gene symbol | SENP7 |
|---|---|
| Entrez ID | 57337 |
| Gene full name | SUMO1/sentrin specific peptidase 7 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005622 | Intracellular | IDA | cellular_component |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0008234 | Cysteine-type peptidase activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9913266175 | 0.0011094183 | 0.9999902473 | 0.0634088553 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4964194023 |
| GSE13712_SHEAR | Down | -0.1938279514 |
| GSE13712_STATIC | Down | -0.1311555366 |
| GSE19018 | Up | 0.0150454620 |
| GSE19899_A1 | Down | -0.3515203128 |
| GSE19899_A2 | Down | -2.7485820453 |
| PubMed_21979375_A1 | Down | -2.5388485183 |
| PubMed_21979375_A2 | Down | -2.4538581109 |
| GSE35957 | Down | -0.5203457580 |
| GSE36640 | Down | -1.2389650739 |
| GSE54402 | Down | -0.7130735159 |
| GSE9593 | Down | -0.4822497453 |
| GSE43922 | Down | -1.0390237606 |
| GSE24585 | Up | 0.5027256676 |
| GSE37065 | Down | -0.1929828084 |
| GSE28863_A1 | Up | 0.1910131652 |
| GSE28863_A2 | Down | -0.0588728896 |
| GSE28863_A3 | Down | -0.3961044086 |
| GSE28863_A4 | Down | -0.3168955630 |
| GSE48662 | Down | -0.1454423196 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7a-3p | MIMAT0004481 | MIRT039004 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-421 | MIMAT0003339 | MIRT039376 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26527005 | SPOP E3 Ubiquitin Ligase Adaptor Promotes Cellular Senescence by Degrading the SENP7 deSUMOylase |
| 26527005 | Here, we show that SPOP promotes senescence, an important tumor suppression mechanism, by targeting the SENP7 deSUMOylase for degradation |
| 26527005 | This correlates with ubiquitin-mediated degradation of SENP7, which promotes senescence by increasing HP1alpha sumoylation and the associated epigenetic gene silencing |
| 26527005 | These phenotypes correlate with ubiquitination and degradation of SENP7 and HP1alpha sumoylation, subcellular re-localization, and its associated gene silencing |
| 26527005 | Furthermore, SENP7 is expressed at higher levels in prostate tumor specimens with SPOP mutation (n = 13) compared to those with wild-type SPOP (n = 80) |
| 26527005 | In summary, SPOP acts as a tumor suppressor by promoting senescence through degrading SENP7 |
| 23045645 | Two Sentrin/small ubiquitin-like modifier (SUMO)-specific protease 7 (SENP7) variants are naturally expressed in breast epithelia |
| 23045645 | Breast cancer (BCa) onset down-regulates the short SENP7 splice variant (SENP7S) and enhances the long transcript (SENP7L) |
| 23045645 | Thus, differential splicing of the SENP7 regulates either tumor suppression or progression |
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