HCSGD entry for PTGER3

1. General information

Official gene symbolPTGER3
Entrez ID5733
Gene full nameprostaglandin E receptor 3 (subtype EP3)
Other gene symbolsEP3 EP3-I EP3-II EP3-III EP3-IV EP3e PGE2-R
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001660Fever generationIEAbiological_process
GO:0004879Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityTASmolecular_function
GO:0004957Prostaglandin E receptor activityIEA NASmolecular_function
GO:0005635Nuclear envelopeTAScellular_component
GO:0005886Plasma membraneIEA TAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006351Transcription, DNA-templatedTASbiological_process
GO:0006355Regulation of transcription, DNA-templatedTASbiological_process
GO:0006357Regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0006366Transcription from RNA polymerase II promoterTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007188Adenylate cyclase-modulating G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0007200Phospholipase C-activating G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationIEAbiological_process
GO:0008150Biological_processNDbiological_process
GO:0008219Cell deathTASbiological_process
GO:0015701Bicarbonate transportIEAbiological_process
GO:0016021Integral component of membraneIEA NAScellular_component
GO:0030522Intracellular receptor signaling pathwayTASbiological_process
GO:0031622Positive regulation of fever generationISSbiological_process
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0035810Positive regulation of urine volumeIEAbiological_process
GO:2001141Regulation of RNA biosynthetic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.30879198740.53732650740.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0796498978
GSE13712_SHEARDown-0.1003892175
GSE13712_STATICUp0.0161805346
GSE19018Up0.0323944861
GSE19899_A1Up0.0246550261
GSE19899_A2Up0.0370091813
PubMed_21979375_A1Up0.1068979003
PubMed_21979375_A2Down-0.0630813676
GSE35957Up0.8766799643
GSE36640Up0.0133367759
GSE54402Up0.2642461852
GSE9593Down-0.0214077122
GSE43922Up0.0852943604
GSE24585Up0.1620798240
GSE37065Down-0.0172090071
GSE28863_A1Down-0.5481635183
GSE28863_A2Up1.1354150640
GSE28863_A3Down-0.7255467639
GSE28863_A4Down-0.1450267750
GSE48662Up0.0782925102

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

BimatoprostDB00905 APRD00826 | DB06863
MisoprostolDB00929 APRD00037

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24046862Treatment with agonists, antagonists and silencing of the EP receptors by siRNA revealed that EP3 was the most involved in transducing the intracrine effects of PGE2
24046862Immunofluorescence experiments confirmed that EP3 was more localized in the cytoplasm than at the cell surface
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