HCSGD entry for BAG1
1. General information
| Official gene symbol | BAG1 |
|---|---|
| Entrez ID | 573 |
| Gene full name | BCL2-associated athanogene |
| Other gene symbols | BAG-1 HAP RAP46 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005057 | Receptor signaling protein activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0007166 | Cell surface receptor signaling pathway | TAS | biological_process |
| GO:0030182 | Neuron differentiation | IEA | biological_process |
| GO:0035556 | Intracellular signal transduction | TAS | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | IEA TAS | biological_process |
| GO:0043525 | Positive regulation of neuron apoptotic process | IEA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0051087 | Chaperone binding | IEA | molecular_function |
| GO:0051219 | Phosphoprotein binding | IEA | molecular_function |
| GO:0070389 | Chaperone cofactor-dependent protein refolding | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6354185631 | 0.1654258843 | 0.9999902473 | 0.7871059653 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.9591948990 |
| GSE13712_SHEAR | Down | -0.3862514319 |
| GSE13712_STATIC | Up | 0.0335154522 |
| GSE19018 | Down | -0.5335802517 |
| GSE19899_A1 | Down | -0.1905341600 |
| GSE19899_A2 | Down | -0.2700193393 |
| PubMed_21979375_A1 | Up | 0.1131217016 |
| PubMed_21979375_A2 | Up | 0.0003409674 |
| GSE35957 | Up | 0.0969160331 |
| GSE36640 | Down | -0.3779144781 |
| GSE54402 | Down | -0.2684034345 |
| GSE9593 | Up | 0.0130946119 |
| GSE43922 | Up | 0.0480791504 |
| GSE24585 | Down | -0.3506839290 |
| GSE37065 | Up | 0.3319717582 |
| GSE28863_A1 | Down | -0.0538624258 |
| GSE28863_A2 | Down | -0.0351899587 |
| GSE28863_A3 | Down | -0.0406119115 |
| GSE28863_A4 | Up | 0.0913649822 |
| GSE48662 | Up | 0.0384120515 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| (2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol | DB07045 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-182-5p | MIMAT0000259 | MIRT047188 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22146591 | A proteomics survey indicated that high levels of BCL2-associated athanogene 2 (BAG2) were found in response to c-Myc repression in TRE293 cells |
| 21681022 | There is a reciprocal change in the expression of two members of the BAG (Bcl-2-associated athanogen) family, BAG1 and BAG3, during cellular aging and under acute stress ("BAG1-BAG3-switch") |
| 20969773 | Moreover, a slight upregulation of the oncogene c-Myc, along with an undetectable level of breast tumor-related gene Bag-1 and TRPS-1, was observed in BME65Cs cells while these genes are all highly expressed in MCF-7 |
| 19229298 | We examined the specific roles of BAG1 and BAG3 in protein degradation during the aging process |
| 19229298 | We show that BAG1 and BAG3 regulate proteasomal and macroautophagic pathways, respectively, for the degradation of polyubiquitinated proteins |
| 19229298 | Moreover, using models of cellular aging, we find that a switch from BAG1 to BAG3 determines that aged cells use more intensively the macroautophagic system for turnover of polyubiquitinated proteins |
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