HCSGD entry for PTAFR
1. General information
| Official gene symbol | PTAFR |
|---|---|
| Entrez ID | 5724 |
| Gene full name | platelet-activating factor receptor |
| Other gene symbols | PAFR |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001530 | Lipopolysaccharide binding | IEA | molecular_function |
| GO:0001816 | Cytokine production | IEA | biological_process |
| GO:0001875 | Lipopolysaccharide receptor activity | IEA | molecular_function |
| GO:0004930 | G-protein coupled receptor activity | TAS | molecular_function |
| GO:0004992 | Platelet activating factor receptor activity | IDA | molecular_function |
| GO:0005543 | Phospholipid binding | IDA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IDA TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006935 | Chemotaxis | IEA | biological_process |
| GO:0006954 | Inflammatory response | IEA | biological_process |
| GO:0006955 | Immune response | TAS | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | IMP | biological_process |
| GO:0016020 | Membrane | IDA | cellular_component |
| GO:0016021 | Integral component of membrane | NAS | cellular_component |
| GO:0019221 | Cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0032959 | Inositol trisphosphate biosynthetic process | IEA | biological_process |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0048015 | Phosphatidylinositol-mediated signaling | IDA | biological_process |
| GO:0060333 | Interferon-gamma-mediated signaling pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7101229703 | 0.3434737472 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0135579534 |
| GSE13712_SHEAR | Up | 0.0300738237 |
| GSE13712_STATIC | Down | -0.1799584595 |
| GSE19018 | Down | -0.0335068379 |
| GSE19899_A1 | Down | -0.0458716422 |
| GSE19899_A2 | Up | 0.1608186839 |
| PubMed_21979375_A1 | Up | 0.0474658515 |
| PubMed_21979375_A2 | Down | -0.0091119036 |
| GSE35957 | Up | 0.1588480071 |
| GSE36640 | Down | -0.1353375912 |
| GSE54402 | Up | 0.0160747885 |
| GSE9593 | Up | 0.0678020109 |
| GSE43922 | Up | 0.0321652612 |
| GSE24585 | Up | 0.0187904771 |
| GSE37065 | Down | -0.0121456739 |
| GSE28863_A1 | Down | -0.7103253006 |
| GSE28863_A2 | Down | -0.5358213362 |
| GSE28863_A3 | Down | -0.0371905020 |
| GSE28863_A4 | Up | 0.2657808543 |
| GSE48662 | Up | 0.5356840063 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017043 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22981852 | Previously we have demonstrated that cellular senescence enhances permissiveness for bacterial pneumonia through increased expression of the bacterial ligands Laminin receptor (LR), Platelet-activating factor receptor (PAFr) and Cytokeratin 10 (K10) |
| 22981852 | Mice on eRapa also had marked reductions in PAFr, LR, and K10 |
| 21615674 | Keratin 10 (K10), laminin receptor (LR), and platelet-activating factor receptor (PAFr), host proteins known to be co-opted for bacterial adhesion, were also increased |
| 21615674 | Additionally, exposure of normal cells to conditioned media from senescent cells doubled PAFr levels and pneumococcal adherence |
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