HCSGD entry for SMEK2
1. General information
| Official gene symbol | SMEK2 |
|---|---|
| Entrez ID | 57223 |
| Gene full name | SMEK homolog 2, suppressor of mek1 (Dictyostelium) |
| Other gene symbols | FLFL2 PP4R3B PSY2 smk1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005815 | Microtubule organizing center | IEA | cellular_component |
| GO:0006470 | Protein dephosphorylation | IEA | biological_process |
| GO:0019216 | Regulation of lipid metabolic process | IEA | biological_process |
| GO:0030289 | Protein phosphatase 4 complex | IEA | cellular_component |
| GO:0045722 | Positive regulation of gluconeogenesis | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3732984993 | 0.5627985981 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1285364573 |
| GSE13712_SHEAR | Up | 0.0436777304 |
| GSE13712_STATIC | Down | -0.0505937500 |
| GSE19018 | Down | -0.4205558511 |
| GSE19899_A1 | Up | 0.0462045325 |
| GSE19899_A2 | Down | -0.0079130602 |
| PubMed_21979375_A1 | Up | 0.6619493065 |
| PubMed_21979375_A2 | Up | 0.1346328353 |
| GSE35957 | Down | -0.0557968748 |
| GSE36640 | Down | -0.2329618081 |
| GSE54402 | Up | 0.2570719104 |
| GSE9593 | Down | -0.0786428054 |
| GSE43922 | Up | 0.0120185880 |
| GSE24585 | Down | -0.0254647656 |
| GSE37065 | Down | -0.0125161850 |
| GSE28863_A1 | Up | 0.5030252143 |
| GSE28863_A2 | Up | 0.6598624537 |
| GSE28863_A3 | Down | -0.3712654129 |
| GSE28863_A4 | Down | -0.2008757651 |
| GSE48662 | Down | -0.0828787761 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-106b-5p | MIMAT0000680 | MIRT044263 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-31-5p | MIMAT0000089 | MIRT049885 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051269 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
