HCSGD entry for BAD

1. General information

Official gene symbolBAD
Entrez ID572
Gene full nameBCL2-associated agonist of cell death
Other gene symbolsBBC2 BCL2L8
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001666Response to hypoxiaIEAbiological_process
GO:0001836Release of cytochrome c from mitochondriaIEAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005543Phospholipid bindingIMPmolecular_function
GO:0005739MitochondrionIDA IEAcellular_component
GO:0005741Mitochondrial outer membraneIDA TAScellular_component
GO:0005829CytosolIDA IEA TAScellular_component
GO:0006007Glucose catabolic processIEAbiological_process
GO:0006915Apoptotic processIDA TASbiological_process
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processISSbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0008289Lipid bindingIDAmolecular_function
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0008625Extrinsic apoptotic signaling pathway via death domain receptorsIEAbiological_process
GO:0008630Intrinsic apoptotic signaling pathway in response to DNA damageIEAbiological_process
GO:0008656Cysteine-type endopeptidase activator activity involved in apoptotic processIDA IEAmolecular_function
GO:0009749Response to glucoseIEAbiological_process
GO:0010508Positive regulation of autophagyTASbiological_process
GO:0010918Positive regulation of mitochondrial membrane potentialIEA ISSbiological_process
GO:0019050Suppression by virus of host apoptotic processIEAbiological_process
GO:0019221Cytokine-mediated signaling pathwayIEAbiological_process
GO:0019901Protein kinase bindingIPImolecular_function
GO:0030346Protein phosphatase 2B bindingIEAmolecular_function
GO:0032024Positive regulation of insulin secretionISSbiological_process
GO:0032355Response to estradiolIEAbiological_process
GO:0032570Response to progesteroneIEAbiological_process
GO:0033133Positive regulation of glucokinase activityIEA ISSbiological_process
GO:0033574Response to testosteroneIEAbiological_process
GO:0034201Response to oleic acidIEAbiological_process
GO:0035774Positive regulation of insulin secretion involved in cellular response to glucose stimulusIEAbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042542Response to hydrogen peroxideIEAbiological_process
GO:0042593Glucose homeostasisIEA ISSbiological_process
GO:0043065Positive regulation of apoptotic processIDA IMP TASbiological_process
GO:0043200Response to amino acidIEAbiological_process
GO:0043280Positive regulation of cysteine-type endopeptidase activity involved in apoptotic processIDAbiological_process
GO:0043422Protein kinase B bindingIEAmolecular_function
GO:0044342Type B pancreatic cell proliferationIEA ISSbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045471Response to ethanolIEAbiological_process
GO:0045579Positive regulation of B cell differentiationIEAbiological_process
GO:0045582Positive regulation of T cell differentiationIEAbiological_process
GO:0045862Positive regulation of proteolysisIDAbiological_process
GO:0046031ADP metabolic processIEA ISSbiological_process
GO:0046034ATP metabolic processIEA ISSbiological_process
GO:0046902Regulation of mitochondrial membrane permeabilityIMPbiological_process
GO:0046931Pore complex assemblyIDAbiological_process
GO:0046982Protein heterodimerization activityIEAmolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048015Phosphatidylinositol-mediated signalingTASbiological_process
GO:0050679Positive regulation of epithelial cell proliferationIMPbiological_process
GO:0051384Response to glucocorticoidIEAbiological_process
GO:0051592Response to calcium ionIEAbiological_process
GO:0060139Positive regulation of apoptotic process by virusIEAbiological_process
GO:0060154Cellular process regulating host cell cycle in response to virusIEAbiological_process
GO:0071247Cellular response to chromateIEAbiological_process
GO:0071260Cellular response to mechanical stimulusIEPbiological_process
GO:0071316Cellular response to nicotineIDAbiological_process
GO:0071396Cellular response to lipidIEAbiological_process
GO:0071456Cellular response to hypoxiaIEPbiological_process
GO:0090200Positive regulation of release of cytochrome c from mitochondriaIMPbiological_process
GO:0097190Apoptotic signaling pathwayTASbiological_process
GO:0097191Extrinsic apoptotic signaling pathwayIMPbiological_process
GO:0097192Extrinsic apoptotic signaling pathway in absence of ligandIEAbiological_process
GO:0097193Intrinsic apoptotic signaling pathwayIMP TASbiological_process
GO:0097202Activation of cysteine-type endopeptidase activityIDAbiological_process
GO:1900740Positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayTASbiological_process
GO:1901216Positive regulation of neuron deathIEAbiological_process
GO:2000078Positive regulation of type B pancreatic cell developmentIEA ISSbiological_process
GO:2001244Positive regulation of intrinsic apoptotic signaling pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.85848505000.41882839180.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1684215490
GSE13712_SHEARDown-0.4776832095
GSE13712_STATICDown-0.1850164710
GSE19018Up0.1885990148
GSE19899_A1Down-0.2042290417
GSE19899_A2Up0.0847902482
PubMed_21979375_A1Down-0.2728703486
PubMed_21979375_A2Down-0.1825315310
GSE35957Down-0.1200342732
GSE36640Up0.1086258360
GSE54402Down-0.0088181298
GSE9593Up0.2354800704
GSE43922Up0.0174790467
GSE24585Up0.0573054528
GSE37065Down-0.1649492798
GSE28863_A1Down-0.0733724907
GSE28863_A2Down-0.1599144955
GSE28863_A3Up0.1753207239
GSE28863_A4Down-0.0005659505
GSE48662Up0.1458552905

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

ABT-263DB05764 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-330-5pMIMAT0004693MIRT038239CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.