HCSGD entry for PELI1

1. General information

Official gene symbolPELI1
Entrez ID57162
Gene full namepellino E3 ubiquitin protein ligase 1
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001819Positive regulation of cytokine productionIEAbiological_process
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0004842Ubiquitin-protein ligase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0008063Toll signaling pathwayIEAbiological_process
GO:0030890Positive regulation of B cell proliferationIEAbiological_process
GO:0031398Positive regulation of protein ubiquitinationIEAbiological_process
GO:0032088Negative regulation of NF-kappaB transcription factor activityIEAbiological_process
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034141Positive regulation of toll-like receptor 3 signaling pathwayIEAbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034145Positive regulation of toll-like receptor 4 signaling pathwayIEAbiological_process
GO:0034146Toll-like receptor 5 signaling pathwayTASbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0034166Toll-like receptor 10 signaling pathwayTASbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0042130Negative regulation of T cell proliferationIEAbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingTASbiological_process
GO:0043331Response to dsRNAIEAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0070936Protein K48-linked ubiquitinationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01148160400.68888772460.27110950671.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.4206276969
GSE13712_SHEARDown-0.0828736975
GSE13712_STATICUp0.1895042985
GSE19018Down-0.2065274725
GSE19899_A1Up0.7282981480
GSE19899_A2Up0.7566118156
PubMed_21979375_A1Up1.3439081606
PubMed_21979375_A2Up0.5169899412
GSE35957Down-0.4268210664
GSE36640Down-0.1118036647
GSE54402Up1.2792429508
GSE9593Down-0.2940260569
GSE43922Up1.6132085696
GSE24585Down-0.3663961144
GSE37065Up0.6406335130
GSE28863_A1Up0.0502607468
GSE28863_A2Up0.2999005212
GSE28863_A3Down-0.1260790453
GSE28863_A4Down-0.1762531685
GSE48662Up0.1224772452

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT005096MicroarrayFunctional MTI (Weak)19193853
hsa-miR-155-5pMIMAT0000646MIRT005096ProteomicsFunctional MTI (Weak)18668040
hsa-miR-374b-5pMIMAT0004955MIRT016081SequencingFunctional MTI (Weak)20371350
hsa-miR-340-5pMIMAT0004692MIRT019644SequencingFunctional MTI (Weak)20371350
hsa-miR-21-5pMIMAT0000076MIRT031077SequencingFunctional MTI (Weak)20371350
hsa-miR-21-5pMIMAT0000076MIRT031077MicroarrayFunctional MTI (Weak)18591254
hsa-miR-296-3pMIMAT0004679MIRT038510CLASHFunctional MTI (Weak)23622248
hsa-miR-106a-5pMIMAT0000103MIRT048318CLASHFunctional MTI (Weak)23622248
hsa-miR-17-5pMIMAT0000070MIRT050853CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-21-5pMIMAT0000076NAhsa-miR-2120167875
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.