HCSGD entry for RTN4
1. General information
| Official gene symbol | RTN4 |
|---|---|
| Entrez ID | 57142 |
| Gene full name | reticulon 4 |
| Other gene symbols | ASY NI220/250 NOGO NOGO-A NOGOC NSP NSP-CL Nbla00271 Nbla10545 Nogo-B Nogo-C RTN-X RTN4-A RTN4-B1 RTN4-B2 RTN4-C |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001525 | Angiogenesis | IEA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005635 | Nuclear envelope | IDA | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IEA NAS | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006915 | Apoptotic process | NAS | biological_process |
| GO:0007413 | Axonal fasciculation | IEA ISS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0021801 | Cerebral cortex radial glia guided migration | IEA ISS | biological_process |
| GO:0030176 | Integral component of endoplasmic reticulum membrane | IDA | cellular_component |
| GO:0030308 | Negative regulation of cell growth | IMP | biological_process |
| GO:0030334 | Regulation of cell migration | IDA | biological_process |
| GO:0030517 | Negative regulation of axon extension | IDA | biological_process |
| GO:0042981 | Regulation of apoptotic process | NAS | biological_process |
| GO:0042995 | Cell projection | IEA | cellular_component |
| GO:0043025 | Neuronal cell body | IEA | cellular_component |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0050770 | Regulation of axonogenesis | TAS | biological_process |
| GO:0050771 | Negative regulation of axonogenesis | TAS | biological_process |
| GO:0060317 | Cardiac epithelial to mesenchymal transition | IEA | biological_process |
| GO:0071786 | Endoplasmic reticulum tubular network organization | IMP | biological_process |
| GO:2000172 | Regulation of branching morphogenesis of a nerve | IEA ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7713468523 | 0.2340448387 | 0.9999902473 | 0.9318074561 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0018141945 |
| GSE13712_SHEAR | Up | 0.2816492918 |
| GSE13712_STATIC | Up | 0.2152079832 |
| GSE19018 | Up | 0.1554920034 |
| GSE19899_A1 | Down | -0.0441932794 |
| GSE19899_A2 | Down | -0.2144319159 |
| PubMed_21979375_A1 | Down | -0.8130557112 |
| PubMed_21979375_A2 | Down | -0.1010658823 |
| GSE35957 | Up | 0.0281819087 |
| GSE36640 | Up | 0.3151832970 |
| GSE54402 | Down | -0.3304693627 |
| GSE9593 | Up | 0.2950423702 |
| GSE43922 | Down | -0.2070905887 |
| GSE24585 | Down | -0.2903697076 |
| GSE37065 | Down | -0.0883160032 |
| GSE28863_A1 | Up | 0.0571152321 |
| GSE28863_A2 | Up | 0.4731645696 |
| GSE28863_A3 | Down | -0.1299490174 |
| GSE28863_A4 | Down | -0.3435063742 |
| GSE48662 | Down | -0.0139213111 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-21-5p | MIMAT0000076 | MIRT000167 | Luciferase reporter assay//Quantitative proteomic approach | Functional MTI | 19253296 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT001421 | pSILAC//Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT001421 | Microarray | Functional MTI (Weak) | 21199864 |
| hsa-miR-148b-3p | MIMAT0000759 | MIRT019491 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-132-3p | MIMAT0000426 | MIRT021845 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT024991 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025475 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025475 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-101-3p | MIMAT0000099 | MIRT027341 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-33a-5p | MIMAT0000091 | MIRT028224 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-320a | MIMAT0000510 | MIRT044751 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047850 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
