HCSGD entry for PSMD8

1. General information

Official gene symbolPSMD8
Entrez ID5714
Gene full nameproteasome (prosome, macropain) 26S subunit, non-ATPase, 8
Other gene symbolsHIP6 HYPF Nin1p Rpn12 S14 p31
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0000209Protein polyubiquitinationTASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0000502Proteasome complexTAScellular_component
GO:0002474Antigen processing and presentation of peptide antigen via MHC class ITASbiological_process
GO:0002479Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTASbiological_process
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005838Proteasome regulatory particleIEAcellular_component
GO:0006508ProteolysisIEAbiological_process
GO:0006521Regulation of cellular amino acid metabolic processTASbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestTASbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0016032Viral processTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0022624Proteasome accessory complexISScellular_component
GO:0031145Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processTASbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0042590Antigen processing and presentation of exogenous peptide antigen via MHC class ITASbiological_process
GO:0042981Regulation of apoptotic processTASbiological_process
GO:0043066Negative regulation of apoptotic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0051436Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051437Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051439Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.02475788150.88297375480.37131737891.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.7835028288
GSE13712_SHEARDown-0.0376852649
GSE13712_STATICDown-0.0220279441
GSE19018Up0.0449034626
GSE19899_A1Up0.6554669471
GSE19899_A2Up0.7250005450
PubMed_21979375_A1Up1.6865703962
PubMed_21979375_A2Up0.4097821911
GSE35957Down-0.2888359219
GSE36640Up0.0948804761
GSE54402Up0.8820980780
GSE9593Up0.2685631199
GSE43922Up0.3999506450
GSE24585Down-0.0335943636
GSE37065Down-0.0361007487
GSE28863_A1Down-0.3537926486
GSE28863_A2Down-0.3759880189
GSE28863_A3Up0.0096225144
GSE28863_A4Up0.1132060979
GSE48662Down-0.2006502448

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-425-5pMIMAT0003393MIRT039343CLASHFunctional MTI (Weak)23622248
hsa-miR-615-3pMIMAT0003283MIRT040097CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT041805CLASHFunctional MTI (Weak)23622248
hsa-miR-423-3pMIMAT0001340MIRT042550CLASHFunctional MTI (Weak)23622248
hsa-miR-186-5pMIMAT0000456MIRT045234CLASHFunctional MTI (Weak)23622248
hsa-miR-149-5pMIMAT0000450MIRT045550CLASHFunctional MTI (Weak)23622248
hsa-miR-196a-5pMIMAT0000226MIRT048193CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.