HCSGD entry for PNPLA2
1. General information
| Official gene symbol | PNPLA2 |
|---|---|
| Entrez ID | 57104 |
| Gene full name | patatin-like phospholipase domain containing 2 |
| Other gene symbols | 1110001C14Rik ATGL PEDF-R TTS-2.2 TTS2 iPLA2zeta |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004806 | Triglyceride lipase activity | ISS | molecular_function |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0005811 | Lipid particle | IDA | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0006644 | Phospholipid metabolic process | TAS | biological_process |
| GO:0010891 | Negative regulation of sequestering of triglyceride | IDA | biological_process |
| GO:0010898 | Positive regulation of triglyceride catabolic process | IDA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0019433 | Triglyceride catabolic process | IEA | biological_process |
| GO:0036155 | Acylglycerol acyl-chain remodeling | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046474 | Glycerophospholipid biosynthetic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0963546712 | 0.8341998214 | 0.6491022222 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1358445403 |
| GSE13712_SHEAR | Down | -0.2803344855 |
| GSE13712_STATIC | Down | -0.3202190251 |
| GSE19018 | Up | 0.1763631490 |
| GSE19899_A1 | Down | -0.1764990432 |
| GSE19899_A2 | Up | 0.3024258451 |
| PubMed_21979375_A1 | Down | -0.0378466220 |
| PubMed_21979375_A2 | Up | 0.2959921583 |
| GSE35957 | Up | 0.0387796950 |
| GSE36640 | Up | 0.9582468441 |
| GSE54402 | Down | -0.0296259084 |
| GSE9593 | Down | -0.2306785949 |
| GSE43922 | Down | -0.0094772583 |
| GSE24585 | Up | 0.7294604083 |
| GSE37065 | Up | 0.0107980154 |
| GSE28863_A1 | Up | 0.3610293770 |
| GSE28863_A2 | Up | 0.0349235201 |
| GSE28863_A3 | Up | 0.1366229392 |
| GSE28863_A4 | Down | -0.0860473782 |
| GSE48662 | Up | 0.7606078439 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-148b-3p | MIMAT0000759 | MIRT019467 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT023204 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23583398 | Adipose triglyceride lipase (ATGL) exerts major TG catalytic activity in both adipotic and non-adipotic cells |
| 23583398 | ATGL(-/-)mSMC showed spontaneous TG accumulation with lower mitogenic response and smooth muscle actin (SMA) expression compared to ATGL (+/+)mSMC |
| 23583398 | Next, ectopic gene transfer of human ATGL was attempted using doxycycline (Dox)-regulatable myc-DDK-tagged adenovirus vector (AdvATGL) |
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