HCSGD entry for PSMD4

1. General information

Official gene symbolPSMD4
Entrez ID5710
Gene full nameproteasome (prosome, macropain) 26S subunit, non-ATPase, 4
Other gene symbolsAF AF-1 ASF MCB1 Rpn10 S5A pUB-R5
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0000209Protein polyubiquitinationTASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0000502Proteasome complexTAScellular_component
GO:0002474Antigen processing and presentation of peptide antigen via MHC class ITASbiological_process
GO:0002479Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTASbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006511Ubiquitin-dependent protein catabolic processIEAbiological_process
GO:0006521Regulation of cellular amino acid metabolic processTASbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestTASbiological_process
GO:0008540Proteasome regulatory particle, base subcomplexIEAcellular_component
GO:0010467Gene expressionTASbiological_process
GO:0016032Viral processTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0022624Proteasome accessory complexISScellular_component
GO:0031145Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processTASbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0042590Antigen processing and presentation of exogenous peptide antigen via MHC class ITASbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0042981Regulation of apoptotic processTASbiological_process
GO:0043066Negative regulation of apoptotic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0051436Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051437Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051439Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.21951729800.91151929640.90125016381.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.5611842691
GSE13712_SHEARDown-0.0731152468
GSE13712_STATICUp0.0510720045
GSE19018Up0.2993912820
GSE19899_A1Down-0.0676745865
GSE19899_A2Up0.2862702341
PubMed_21979375_A1Down-0.0196219573
PubMed_21979375_A2Down-0.4231706990
GSE35957Down-0.1846941903
GSE36640Up0.1416505811
GSE54402Up0.2985104312
GSE9593Down-0.1292550165
GSE43922Up0.0444482464
GSE24585Up0.1917638317
GSE37065Down-0.0567792651
GSE28863_A1Up0.0869271023
GSE28863_A2Down-0.0219407222
GSE28863_A3Up0.0745761734
GSE28863_A4Up0.2690772971
GSE48662Down-0.0002881003

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-744-5pMIMAT0004945MIRT037698CLASHFunctional MTI (Weak)23622248
hsa-miR-324-5pMIMAT0000761MIRT043083CLASHFunctional MTI (Weak)23622248
hsa-miR-186-5pMIMAT0000456MIRT044963CLASHFunctional MTI (Weak)23622248
hsa-miR-221-3pMIMAT0000278MIRT046856CLASHFunctional MTI (Weak)23622248
hsa-miR-93-5pMIMAT0000093MIRT048850CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.