HCSGD entry for BACH1

1. General information

Official gene symbolBACH1
Entrez ID571
Gene full nameBTB and CNC homology 1, basic leucine zipper transcription factor 1
Other gene symbolsBACH-1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000083Regulation of transcription involved in G1/S transition of mitotic cell cycleIMPbiological_process
GO:0000117Regulation of transcription involved in G2/M transition of mitotic cell cycleIMPbiological_process
GO:0000122Negative regulation of transcription from RNA polymerase II promoterIMPbiological_process
GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptionIDA IMPmolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEA ISSmolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005829CytosolIDAcellular_component
GO:0006355Regulation of transcription, DNA-templatedISSbiological_process
GO:0006366Transcription from RNA polymerase II promoterIDA IMPbiological_process
GO:0020037Heme bindingNASmolecular_function
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0061418Regulation of transcription from RNA polymerase II promoter in response to hypoxiaIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.44883771890.54613330800.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.5438010198
GSE13712_SHEARUp0.3109705081
GSE13712_STATICDown-0.0140107242
GSE19018Up0.1948899580
GSE19899_A1Up0.0559982701
GSE19899_A2Down-0.1404498901
PubMed_21979375_A1Up0.0182858373
PubMed_21979375_A2Up0.0038398981
GSE35957Up0.2481387080
GSE36640Down-0.4202755744
GSE54402Up0.1673364675
GSE9593Up0.1403712344
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Up0.4082567483
GSE28863_A2Up0.4117142997
GSE28863_A3Down-0.4447052311
GSE28863_A4Down-0.0309883614
GSE48662Down-0.2424690386

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT001043Luciferase reporter assay//Microarray//qRT-PCRFunctional MTI19193853
hsa-miR-155-5pMIMAT0000646MIRT001043qRT-PCR//Luciferase reporter assayFunctional MTI18299402
hsa-miR-155-5pMIMAT0000646MIRT001043Luciferase reporter assayFunctional MTI18367535
hsa-miR-155-5pMIMAT0000646MIRT001043Immunohistochemistry//In situ hybridization//Luciferase reporter assay//Microarray//qRT-PCR//Western blotFunctional MTI21541331
hsa-miR-155-5pMIMAT0000646MIRT001043Reporter assay;OtherFunctional MTI20584899
hsa-miR-155-5pMIMAT0000646MIRT001043Reporter assayFunctional MTI17881434
hsa-miR-196a-5pMIMAT0000226MIRT004718Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI20127796
hsa-miR-769-5pMIMAT0003886MIRT039211CLASHFunctional MTI (Weak)23622248
hsa-miR-125b-5pMIMAT0000423MIRT045958CLASHFunctional MTI (Weak)23622248
hsa-miR-20a-5pMIMAT0000075MIRT050569CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.