HCSGD entry for CASC5
1. General information
| Official gene symbol | CASC5 |
|---|---|
| Entrez ID | 57082 |
| Gene full name | cancer susceptibility candidate 5 |
| Other gene symbols | AF15Q14 CT29 D40 KNL1 PPP1R55 hKNL-1 hSpc105 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0000777 | Condensed chromosome kinetochore | IEA | cellular_component |
| GO:0001669 | Acrosomal vesicle | IDA | cellular_component |
| GO:0001675 | Acrosome assembly | NAS | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006334 | Nucleosome assembly | TAS | biological_process |
| GO:0007067 | Mitosis | IEA | biological_process |
| GO:0008608 | Attachment of spindle microtubules to kinetochore | IDA | biological_process |
| GO:0010923 | Negative regulation of phosphatase activity | IDA | biological_process |
| GO:0034080 | CENP-A containing nucleosome assembly at centromere | TAS | biological_process |
| GO:0034501 | Protein localization to kinetochore | IDA | biological_process |
| GO:0071173 | Spindle assembly checkpoint | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6631271456 | 0.0000818928 | 0.9999902473 | 0.0155071942 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4895551558 |
| GSE13712_SHEAR | Down | -0.1376139950 |
| GSE13712_STATIC | Down | -0.3727805517 |
| GSE19018 | Up | 0.1467467324 |
| GSE19899_A1 | Down | -0.5903281089 |
| GSE19899_A2 | Down | -3.0128640350 |
| PubMed_21979375_A1 | Down | -2.8605640497 |
| PubMed_21979375_A2 | Down | -2.4986966834 |
| GSE35957 | Down | -1.4320278884 |
| GSE36640 | Down | -3.8778600977 |
| GSE54402 | Down | -1.1207259815 |
| GSE9593 | Down | -0.6677096872 |
| GSE43922 | Down | -3.3434090560 |
| GSE24585 | Up | 0.2676617538 |
| GSE37065 | Down | -1.0779395510 |
| GSE28863_A1 | Down | -0.3364325217 |
| GSE28863_A2 | Up | 1.7411120357 |
| GSE28863_A3 | Down | -0.6843033746 |
| GSE28863_A4 | Up | 0.6388647775 |
| GSE48662 | Down | -0.6537834412 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-215-5p | MIMAT0000272 | MIRT024486 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026325 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030815 | Microarray | Functional MTI (Weak) | 18591254 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
