HCSGD entry for PSMD2

1. General information

Official gene symbolPSMD2
Entrez ID5708
Gene full nameproteasome (prosome, macropain) 26S subunit, non-ATPase, 2
Other gene symbolsP97 Rpn1 S2 TRAP2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0000209Protein polyubiquitinationTASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0000502Proteasome complexIEA TAScellular_component
GO:0002474Antigen processing and presentation of peptide antigen via MHC class ITASbiological_process
GO:0002479Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTASbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005654NucleoplasmTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0005838Proteasome regulatory particleTAScellular_component
GO:0006521Regulation of cellular amino acid metabolic processTASbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestTASbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0016032Viral processTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0022624Proteasome accessory complexISScellular_component
GO:0030234Enzyme regulator activityIEAmolecular_function
GO:0031145Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processTASbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0042176Regulation of protein catabolic processIEAbiological_process
GO:0042590Antigen processing and presentation of exogenous peptide antigen via MHC class ITASbiological_process
GO:0042981Regulation of apoptotic processTASbiological_process
GO:0043066Negative regulation of apoptotic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0051436Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051437Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051439Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.02015919990.96549408460.34209407221.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.6472286949
GSE13712_SHEARUp0.0942077103
GSE13712_STATICUp0.3188505502
GSE19018Up0.7621402034
GSE19899_A1Up0.4639299880
GSE19899_A2Up0.5559429351
PubMed_21979375_A1Up0.4154290081
PubMed_21979375_A2Up0.3955601765
GSE35957Up0.0523871208
GSE36640Down-0.0705826879
GSE54402Up0.3812148230
GSE9593Up0.0245906415
GSE43922Up0.1695049777
GSE24585Down-0.2280835952
GSE37065Up0.0145696432
GSE28863_A1Down-0.0627648495
GSE28863_A2Up0.4373563073
GSE28863_A3Down-0.2773502749
GSE28863_A4Up0.1183986775
GSE48662Down-0.2634753515

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-200a-3pMIMAT0000682MIRT004400Microarray//Northern blotFunctional MTI (Weak)16331254
hsa-miR-615-3pMIMAT0003283MIRT039985CLASHFunctional MTI (Weak)23622248
hsa-miR-324-3pMIMAT0000762MIRT042898CLASHFunctional MTI (Weak)23622248
hsa-miR-324-5pMIMAT0000761MIRT043028CLASHFunctional MTI (Weak)23622248
hsa-miR-331-3pMIMAT0000760MIRT043381CLASHFunctional MTI (Weak)23622248
hsa-miR-361-5pMIMAT0000703MIRT044106CLASHFunctional MTI (Weak)23622248
hsa-miR-186-5pMIMAT0000456MIRT045290CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049452CLASHFunctional MTI (Weak)23622248
hsa-miR-20a-5pMIMAT0000075MIRT050480CLASHFunctional MTI (Weak)23622248
hsa-let-7e-5pMIMAT0000066MIRT051506CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.