HCSGD entry for PSMC6

1. General information

Official gene symbolPSMC6
Entrez ID5706
Gene full nameproteasome (prosome, macropain) 26S subunit, ATPase, 6
Other gene symbolsCADP44 P44 SUG2 p42
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0000209Protein polyubiquitinationTASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0000502Proteasome complexIDAcellular_component
GO:0002474Antigen processing and presentation of peptide antigen via MHC class ITASbiological_process
GO:0002479Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTASbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0006200ATP catabolic processTASbiological_process
GO:0006511Ubiquitin-dependent protein catabolic processICbiological_process
GO:0006521Regulation of cellular amino acid metabolic processTASbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestTASbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0016032Viral processTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0016234Inclusion bodyIEAcellular_component
GO:0016887ATPase activityTASmolecular_function
GO:0017111Nucleoside-triphosphatase activityIEAmolecular_function
GO:0022624Proteasome accessory complexISScellular_component
GO:0030674Protein binding, bridgingNASmolecular_function
GO:0031145Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processTASbiological_process
GO:0031597Cytosolic proteasome complexIEAcellular_component
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0042590Antigen processing and presentation of exogenous peptide antigen via MHC class ITASbiological_process
GO:0042981Regulation of apoptotic processTASbiological_process
GO:0043066Negative regulation of apoptotic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0051436Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051437Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051439Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0090261Positive regulation of inclusion body assemblyIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.22353096390.68596461000.90402897931.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2279976148
GSE13712_SHEARUp0.0622179231
GSE13712_STATICUp0.0801792559
GSE19018Down-0.2036838556
GSE19899_A1Up0.3404722535
GSE19899_A2Down-0.0299597246
PubMed_21979375_A1Up0.5177116438
PubMed_21979375_A2Up0.0447414585
GSE35957Up0.0082463594
GSE36640Down-0.1923482070
GSE54402Up0.4531554859
GSE9593Down-0.3216180175
GSE43922Down-0.0453138130
GSE24585Up0.0166416499
GSE37065Up0.0862048566
GSE28863_A1Up0.2363133025
GSE28863_A2Up0.4093524174
GSE28863_A3Down-0.3935719779
GSE28863_A4Up0.0921342809
GSE48662Down-0.4570331054

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT028910MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.