HCSGD entry for PDXP
1. General information
| Official gene symbol | PDXP |
|---|---|
| Entrez ID | 57026 |
| Gene full name | pyridoxal (pyridoxine, vitamin B6) phosphatase |
| Other gene symbols | CIN PLP dJ37E16.5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004647 | Phosphoserine phosphatase activity | IEA | molecular_function |
| GO:0004721 | Phosphoprotein phosphatase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005829 | Cytosol | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006470 | Protein dephosphorylation | IDA | biological_process |
| GO:0007088 | Regulation of mitosis | IMP | biological_process |
| GO:0015629 | Actin cytoskeleton | IDA | cellular_component |
| GO:0030027 | Lamellipodium | IDA | cellular_component |
| GO:0030496 | Midbody | IDA | cellular_component |
| GO:0030836 | Positive regulation of actin filament depolymerization | IMP | biological_process |
| GO:0031072 | Heat shock protein binding | IDA | molecular_function |
| GO:0031247 | Actin rod assembly | IDA IMP | biological_process |
| GO:0031258 | Lamellipodium membrane | IEA | cellular_component |
| GO:0032154 | Cleavage furrow | IDA | cellular_component |
| GO:0032465 | Regulation of cytokinesis | IMP | biological_process |
| GO:0032587 | Ruffle membrane | IDA | cellular_component |
| GO:0033883 | Pyridoxal phosphatase activity | IEA | molecular_function |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0070938 | Contractile ring | IDA | cellular_component |
| GO:0071318 | Cellular response to ATP | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3648926409 | 0.9867379241 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | - | - |
| GSE13712_SHEAR | - | - |
| GSE13712_STATIC | - | - |
| GSE19018 | - | - |
| GSE19899_A1 | - | - |
| GSE19899_A2 | - | - |
| PubMed_21979375_A1 | - | - |
| PubMed_21979375_A2 | - | - |
| GSE35957 | - | - |
| GSE36640 | - | - |
| GSE54402 | - | - |
| GSE9593 | - | - |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Up | 0.1334066359 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-324-5p | MIMAT0000761 | MIRT043152 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043505 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-25-3p | MIMAT0000081 | MIRT050278 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22092365 | OBJECTIVES: Chronic idiopathic neutropenia (CIN) is a disorder of granulopoiesis characterized by the presence of activated T-lymphocytes that induce/sustain apoptosis of bone marrow (BM) granulocytic progenitors |
| 22092365 | T-cell lymphopenia is commonly found in CIN |
| 22092365 | The aim of the study is to probe the mechanisms underlying T-cell lymphopenia in CIN |
| 22092365 | RESULTS: Patients with CIN (n = 44) displayed lower proportion of naive CD45RA(+) cells within the CD4(+) and CD8(+) cells compared with controls (n = 15) |
| 22092365 | The mean relative telomere length of CD4(+) and CD8(+) cells was significantly lower in patients with CIN compared with age-matched controls |
| 22092365 | CONCLUSIONS: The aberrant T-cell expansions associated with the pathogenesis of CIN result in increased proliferation/apoptosis and possibly exhaustion of peripheral blood T cells which, in association with the inadequate compensatory thymic export of new TREC expressing T cells partially because of IL-7 deficiency, may contribute to lymphopenia in CIN |
| 19686285 | Malignant glioma (MG) is highly proliferative and invasive, with the malignant characteristics associated with aneuploidy and chromosomal instability (CIN) |
| 19686285 | These results suggest that GANP protects cells from cellular senescence caused by DNA damage and that a significant decrease in GANP expression leads to malignancy by generating hyperploidy and CIN |
| 18791275 | Meiotic-like division to a aneuploidy: chromosomal instability (CIN), cell-senescence and cancer |
| 17643075 | Evidence based on Bub1 mutations in colorectal cancers suggests it might be a driving force in tumorigenesis via generation of chromosomal instability (CIN) and aneuploidy |
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