HCSGD entry for SMYD2
1. General information
| Official gene symbol | SMYD2 |
|---|---|
| Entrez ID | 56950 |
| Gene full name | SET and MYND domain containing 2 |
| Other gene symbols | HSKM-B KMT3C ZMYND14 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IMP | biological_process |
| GO:0000993 | RNA polymerase II core binding | IEA ISS | molecular_function |
| GO:0002039 | P53 binding | IPI | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA ISS | cellular_component |
| GO:0005737 | Cytoplasm | ISS | cellular_component |
| GO:0005829 | Cytosol | IEA ISS | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | IEA ISS | biological_process |
| GO:0016279 | Protein-lysine N-methyltransferase activity | IDA | molecular_function |
| GO:0018026 | Peptidyl-lysine monomethylation | IDA | biological_process |
| GO:0018027 | Peptidyl-lysine dimethylation | IEA ISS | biological_process |
| GO:0043516 | Regulation of DNA damage response, signal transduction by p53 class mediator | IMP | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0046975 | Histone methyltransferase activity (H3-K36 specific) | IEA ISS | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9791438851 | 0.0542143194 | 0.9999902473 | 0.4386643406 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2031168983 |
| GSE13712_SHEAR | Up | 0.1905842433 |
| GSE13712_STATIC | Up | 0.0135769444 |
| GSE19018 | Up | 0.2548501895 |
| GSE19899_A1 | Down | -0.1880985784 |
| GSE19899_A2 | Down | -0.0825265263 |
| PubMed_21979375_A1 | Down | -0.0809842795 |
| PubMed_21979375_A2 | Down | -0.2198926330 |
| GSE35957 | Down | -0.1859045455 |
| GSE36640 | Down | -0.2705460892 |
| GSE54402 | Down | -0.0821229117 |
| GSE9593 | Down | -0.1547541642 |
| GSE43922 | Up | 0.0040241232 |
| GSE24585 | Down | -0.0720862113 |
| GSE37065 | Down | -0.1037446080 |
| GSE28863_A1 | Down | -0.5444256130 |
| GSE28863_A2 | Down | -0.0454372990 |
| GSE28863_A3 | Down | -0.6780750917 |
| GSE28863_A4 | Down | -0.2080806278 |
| GSE48662 | Down | -0.0242749191 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-130b-3p | MIMAT0000691 | MIRT020273 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029735 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT031254 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
