HCSGD entry for PSMB5

1. General information

Official gene symbolPSMB5
Entrez ID5693
Gene full nameproteasome (prosome, macropain) subunit, beta type, 5
Other gene symbolsLMPX MB1 X
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0000209Protein polyubiquitinationTASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0000502Proteasome complexTAScellular_component
GO:0002474Antigen processing and presentation of peptide antigen via MHC class ITASbiological_process
GO:0002479Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTASbiological_process
GO:0004298Threonine-type endopeptidase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005839Proteasome core complexIEA ISScellular_component
GO:0006521Regulation of cellular amino acid metabolic processTASbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestTASbiological_process
GO:0006979Response to oxidative stressIEAbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0016032Viral processTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0031145Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processTASbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0042590Antigen processing and presentation of exogenous peptide antigen via MHC class ITASbiological_process
GO:0042981Regulation of apoptotic processTASbiological_process
GO:0043066Negative regulation of apoptotic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0051436Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051437Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051439Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051603Proteolysis involved in cellular protein catabolic processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.06068171420.86422299680.53352980641.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.7483077015
GSE13712_SHEARDown-0.2193148157
GSE13712_STATICUp0.0160169891
GSE19018Up0.5265832261
GSE19899_A1Up0.2985841287
GSE19899_A2Up0.4576893906
PubMed_21979375_A1Up0.3425879423
PubMed_21979375_A2Up0.1850528078
GSE35957Down-0.3593218879
GSE36640Up0.3214533004
GSE54402Up0.5164264088
GSE9593Up0.0478671175
GSE43922Up0.1495050488
GSE24585Down-0.4150701997
GSE37065Down-0.1695595236
GSE28863_A1Up0.0680854635
GSE28863_A2Up0.0120286473
GSE28863_A3Down-0.3762337579
GSE28863_A4Up0.2177727381
GSE48662Down-0.1253503769

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Compound

Target

Confidence score

Uniprot

CHEMBL578885CHEMBL46628P28074
CHEMBL591777CHEMBL46628P28074
CHEMBL578478CHEMBL46628P28074
CHEMBL577867CHEMBL46628P28074
CHEMBL578486CHEMBL46628P28074
CHEMBL207579CHEMBL46627P28074
CHEMBL379771CHEMBL46627P28074
CHEMBL379476CHEMBL46627P28074
CHEMBL446443CHEMBL46627P28074
CHEMBL207598CHEMBL46627P28074
CHEMBL207669CHEMBL46627P28074
CHEMBL383529CHEMBL46627P28074
CHEMBL206001CHEMBL46627P28074
CHEMBL207160CHEMBL46627P28074
CHEMBL377532CHEMBL46627P28074
CHEMBL382203CHEMBL46627P28074
CHEMBL382180CHEMBL46627P28074
CHEMBL381089CHEMBL46627P28074
CHEMBL207336CHEMBL46627P28074
CHEMBL207162CHEMBL46627P28074
CHEMBL206206CHEMBL46627P28074
CHEMBL438612CHEMBL46627P28074
CHEMBL381884CHEMBL46627P28074
CHEMBL376815CHEMBL46627P28074
CHEMBL64925CHEMBL46627P28074
CHEMBL204992CHEMBL46627P28074
CHEMBL208019CHEMBL46627P28074
CHEMBL378901CHEMBL46627P28074
CHEMBL208159CHEMBL46627P28074
CHEMBL437115CHEMBL46627P28074
CHEMBL207016CHEMBL46627P28074
CHEMBL204518CHEMBL46627P28074
CHEMBL381735CHEMBL46627P28074
CHEMBL207425CHEMBL46627P28074
CHEMBL438442CHEMBL46627P28074
CHEMBL207403CHEMBL46627P28074
CHEMBL377123CHEMBL46627P28074
CHEMBL437882CHEMBL46627P28074
CHEMBL383673CHEMBL46627P28074
CHEMBL205687CHEMBL46627P28074
CHEMBL381931CHEMBL46627P28074
CHEMBL209243CHEMBL46627P28074
CHEMBL207196CHEMBL46627P28074
CHEMBL383730CHEMBL46627P28074
CHEMBL379772CHEMBL46627P28074
CHEMBL207284CHEMBL46627P28074
CHEMBL207990CHEMBL46627P28074
CHEMBL205757CHEMBL46627P28074
CHEMBL379669CHEMBL46627P28074
CHEMBL206413CHEMBL46627P28074
CHEMBL383122CHEMBL46627P28074
CHEMBL204946CHEMBL46627P28074
CHEMBL383674CHEMBL46627P28074
CHEMBL437311CHEMBL46627P28074
CHEMBL208015CHEMBL46627P28074
CHEMBL207394CHEMBL46627P28074
CHEMBL208372CHEMBL46627P28074
CHEMBL210091CHEMBL46626P28074
CHEMBL208162CHEMBL46626P28074
CHEMBL207990CHEMBL46626P28074
CHEMBL207774CHEMBL46626P28074
CHEMBL210439CHEMBL46626P28074
CHEMBL210901CHEMBL46626P28074
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  • Drugs

Name

Drug

Accession number

(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDEDB08515 -
CarfilzomibDB08889 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-142-3pMIMAT0000434MIRT021543MicroarrayFunctional MTI (Weak)17612493
hsa-miR-18a-5pMIMAT0000072MIRT031323SequencingFunctional MTI (Weak)20371350
hsa-miR-423-3pMIMAT0001340MIRT042548CLASHFunctional MTI (Weak)23622248
hsa-miR-30e-5pMIMAT0000692MIRT044149CLASHFunctional MTI (Weak)23622248
hsa-miR-221-3pMIMAT0000278MIRT046973CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24393841Ameliorating replicative senescence of human bone marrow stromal cells by PSMB5 overexpression
24393841In the present study, we confirmed that proteasomal activity directly contributes to senescence of hBMSCs, which could be reversed by overexpression of the beta5-subunit (PSMB5)
24393841Knocking down PSMB5 led to decreased proteasomal activity concurrent with reduced cell proliferation in early-stage hBMSCs, which is similar to the senescent phenotype observed in late-stage cells
24393841In contrast, overexpressing PSMB5 in late-stage cells efficiently restored the normal activity of 20S proteasomes and promoted cell growth, possibly via upregulating the Cyclin D1/CDK4 complex
24393841Additionally, PSMB5 could enhance cell resistance to oxidative stress, as evidenced by the increased cell survival upon exposing senescent hBMSCs to hydrogen peroxide
24393841Furthermore, PSMB5 overexpression retained the pluripotency of late-stage hBMSCs by facilitating their neural differentiation both in vitro and in vivo
24393841Collectively, our work reveals a critical role of PSMB5 in 20S proteasome-mediated protection against replicative senescence, pointing to a possible strategy for maintaining the integrity of culture-expanded hBMSCs by manipulating the expression of PSMB5
15381105Loss of proteasome function was not associated with decreased proteasome content but with partial replacement of the proteolytic subunit PSMB5 with the inducible subunit LMP7
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