HCSGD entry for SPPL2B
1. General information
| Official gene symbol | SPPL2B |
|---|---|
| Entrez ID | 56928 |
| Gene full name | signal peptide peptidase like 2B |
| Other gene symbols | IMP-4 IMP4 PSH4 PSL1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005765 | Lysosomal membrane | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006509 | Membrane protein ectodomain proteolysis | IDA | biological_process |
| GO:0010008 | Endosome membrane | IDA | cellular_component |
| GO:0030660 | Golgi-associated vesicle membrane | IDA | cellular_component |
| GO:0031293 | Membrane protein intracellular domain proteolysis | IDA IMP | biological_process |
| GO:0042500 | Aspartic endopeptidase activity, intramembrane cleaving | IMP | molecular_function |
| GO:0042803 | Protein homodimerization activity | IDA | molecular_function |
| GO:0050776 | Regulation of immune response | IMP | biological_process |
| GO:0071458 | Integral component of cytoplasmic side of endoplasmic reticulum membrane | IDA | cellular_component |
| GO:0071556 | Integral component of lumenal side of endoplasmic reticulum membrane | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5436805213 | 0.6443204817 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0884697201 |
| GSE13712_SHEAR | Down | -0.1257263928 |
| GSE13712_STATIC | Down | -0.2658424598 |
| GSE19018 | Down | -0.0028986482 |
| GSE19899_A1 | Down | -0.0971294062 |
| GSE19899_A2 | Up | 0.1171552376 |
| PubMed_21979375_A1 | Down | -0.3324480920 |
| PubMed_21979375_A2 | Up | 0.1876435379 |
| GSE35957 | Up | 0.2524283157 |
| GSE36640 | Up | 0.1704105770 |
| GSE54402 | Up | 0.0449944134 |
| GSE9593 | Down | -0.0288918161 |
| GSE43922 | Up | 0.0472448469 |
| GSE24585 | Up | 0.3198083700 |
| GSE37065 | Down | -0.4703248402 |
| GSE28863_A1 | Up | 0.1566767066 |
| GSE28863_A2 | Up | 0.1439011733 |
| GSE28863_A3 | Up | 0.0874711187 |
| GSE28863_A4 | Down | -0.0003425234 |
| GSE48662 | Up | 0.1791044295 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
