HCSGD entry for PAK6


1. General information

Official gene symbolPAK6
Entrez ID56924
Gene full namep21 protein (Cdc42/Rac)-activated kinase 6
Other gene symbolsPAK5
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000278Mitotic cell cycleIBAbiological_process
GO:0004672Protein kinase activityIEAmolecular_function
GO:0004702Receptor signaling protein serine/threonine kinase activityIBAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmIBAcellular_component
GO:0006355Regulation of transcription, DNA-templatedTASbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0007010Cytoskeleton organizationTASbiological_process
GO:0007165Signal transductionIBAbiological_process
GO:0023014Signal transduction by phosphorylationIBAbiological_process
GO:0035556Intracellular signal transductionIBAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.28462279170.95067699180.98378942881.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0156625135
GSE13712_SHEARDown-0.3008108638
GSE13712_STATICUp0.0185684249
GSE19018Up0.0152382436
GSE19899_A1Up0.1271953984
GSE19899_A2Up0.2311958685
PubMed_21979375_A1Down-0.1462582160
PubMed_21979375_A2Up0.0233646677
GSE35957Down-0.0049843925
GSE36640Up0.0866616532
GSE54402Up0.1350599004
GSE9593Down-0.1040800308
GSE43922Up0.0390320212
GSE24585Up0.3065461883
GSE37065Up0.0469724789
GSE28863_A1Down-0.0382258041
GSE28863_A2Up0.4114466746
GSE28863_A3Up0.2433685066
GSE28863_A4Up0.3261131780
GSE48662Up0.0121983573

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-215-5pMIMAT0000272MIRT024945MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026453MicroarrayFunctional MTI (Weak)19074876
hsa-miR-26b-5pMIMAT0000083MIRT029237MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.