HCSGD entry for SPIRE1
1. General information
| Official gene symbol | SPIRE1 |
|---|---|
| Entrez ID | 56907 |
| Gene full name | spire homolog 1 (Drosophila) |
| Other gene symbols | Spir-1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003779 | Actin binding | IEA | molecular_function |
| GO:0005794 | Golgi apparatus | IEA | cellular_component |
| GO:0005856 | Cytoskeleton | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0005938 | Cell cortex | ISS | cellular_component |
| GO:0015031 | Protein transport | IEA | biological_process |
| GO:0016192 | Vesicle-mediated transport | ISS | biological_process |
| GO:0030036 | Actin cytoskeleton organization | IMP | biological_process |
| GO:0030659 | Cytoplasmic vesicle membrane | ISS | cellular_component |
| GO:0032154 | Cleavage furrow | ISS | cellular_component |
| GO:0036089 | Cleavage furrow formation | ISS | biological_process |
| GO:0040038 | Polar body extrusion after meiotic divisions | ISS | biological_process |
| GO:0046907 | Intracellular transport | ISS | biological_process |
| GO:0048193 | Golgi vesicle transport | IEA | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0051295 | Establishment of meiotic spindle localization | IMP | biological_process |
| GO:0070649 | Formin-nucleated actin cable assembly | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0035597432 | 0.9831180806 | 0.1618317241 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4611866706 |
| GSE13712_SHEAR | Up | 0.2541083290 |
| GSE13712_STATIC | Down | -0.0132505639 |
| GSE19018 | Down | -0.5594148249 |
| GSE19899_A1 | Up | 0.6389486520 |
| GSE19899_A2 | Up | 0.8368120130 |
| PubMed_21979375_A1 | Up | 0.8218906042 |
| PubMed_21979375_A2 | Up | 1.0039507730 |
| GSE35957 | Up | 0.1352940915 |
| GSE36640 | Up | 0.0663212937 |
| GSE54402 | Up | 0.6272710712 |
| GSE9593 | Up | 0.9702205602 |
| GSE43922 | Up | 0.5203335407 |
| GSE24585 | Down | -0.2407273123 |
| GSE37065 | Up | 0.0883480476 |
| GSE28863_A1 | Up | 0.5512510964 |
| GSE28863_A2 | Up | 0.3983065391 |
| GSE28863_A3 | Down | -0.0936035939 |
| GSE28863_A4 | Up | 0.1353960549 |
| GSE48662 | Up | 0.6450716458 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018998 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-151a-5p | MIMAT0004697 | MIRT019528 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT021111 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-101-3p | MIMAT0000099 | MIRT027361 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-769-5p | MIMAT0003886 | MIRT039199 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042086 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-99a-5p | MIMAT0000097 | MIRT048628 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
